Clinical Characteristics and Predictors Related to the Progression of Multinodular Goiter Causing Tracheal Compression and Deviation: A Report of Two Cases and Review of the Literature
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- Takamori Toshihiro
- Division of Clinical Laboratory, Tottori University Hospital, Japan
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- Izawa Shoichiro
- Division of Endocrinology and Metabolism, Tottori University Faculty of Medicine, Japan
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- Fukuhara Takahiro
- Department of Otolaryngology, Head and Neck Surgery, Tottori University Faculty of Medicine, Japan
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- Sato Akemi
- Division of Clinical Laboratory, Tottori University Hospital, Japan
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- Ichikawa Hitomi
- Division of Clinical Laboratory, Tottori University Hospital, Japan
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- Motokura Toru
- Division of Clinical Laboratory Medicine, Tottori University Faculty of Medicine, Japan
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- Yamamoto Kazuhiro
- Division of Endocrinology and Metabolism, Tottori University Faculty of Medicine, Japan
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- Fukuda Tetsuya
- Division of Clinical Laboratory, Tottori University Hospital, Japan
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抄録
<p>We describe the clinical course of two patients who developed tracheal compression and deviation by multinodular goiter (MNG). Case 1: A 66-year-old woman presented with thyroid swelling. Five years after the initial admission, she was diagnosed with hyperthyroidism by Graves' disease and increased bilateral thyroid lobes compressing the trachea. Thyroglobulin was elevated from 210 to 472 ng/mL. Case 2: A 52-year-old woman presented with thyroid swelling. Five years after the initial admission, the increased right lobe deviated the trachea and compressed the right recurrent laryngeal nerve. Thyroglobulin was elevated from 122 to 392 ng/mL. Two cases and literature review indicated that MNG with >50 mm, solid components, and extension to the mediastinum or paralarynx were risk factors of tracheal compression and deviation. Monitoring thyroglobulin elevation can help predict the clinical course. </p>
収録刊行物
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- Internal Medicine
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Internal Medicine 61 (9), 1375-1381, 2022-05-01
一般社団法人 日本内科学会