Prognostic Impact of Pretreatment Serum CYFRA Status in 1047 Patients with Esophageal Squamous Cell Carcinoma Who Underwent Radical Resection: A Japan Esophageal Society Promotion Research
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- Ishioka Nobuki
- Department of Clinical Oncology, Toho University Graduate School of Medicine, Tokyo, Japan
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- Suzuki Takashi
- Department of Surgery, School of Medicine, Toho University, Tokyo, Japan
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- Yajima Satoshi
- Department of Surgery, School of Medicine, Toho University, Tokyo, Japan
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- Murakami Kentaro
- Department of Frontier Surgery, Graduate School of Medicine, Chiba University, Chiba, Chiba, Japan
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- Ohkura Yu
- Department of Gastroenterological Surgery, Toranomon Hospital, Tokyo, Japan
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- Fukuda Takashi
- Department of Gastroenterological Surgery, Saitama Prefectural Cancer Center, Saitama, Saitama, Japan
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- Yagi Koichi
- Department of Gastrointestinal Surgery, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
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- Okamura Akihiko
- Department of Gastroenterological Surgery, Cancer Institute Hospital of Japanese Foundation for Cancer Research, Tokyo, Japan
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- Hoshino Isamu
- Division of Gastroenterological Surgery, Chiba Cancer Center, Chiba, Chiba, Japan
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- Kunisaki Chikara
- Department of Surgery, Gastroenterological Center, Yokohama City University Medical Center, Yokohama, Kanagawa, Japan
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- Nakajima Yasuaki
- Department of Gastrointestinal Surgery, Tokyo Medical and Dental University, Tokyo, Japan
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- Narumiya Kosuke
- Department of Surgery, Institute of Gastroenterology, Tokyo Women’s Medical University, Tokyo, Japan
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- Ogawa Ryo
- Department of Gastroenterological Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi, Japan
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- Shimada Hideaki
- Department of Clinical Oncology, Toho University Graduate School of Medicine, Tokyo, Japan Department of Surgery, School of Medicine, Toho University, Tokyo, Japan
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抄録
<p>Purpose: The prognostic significance of pretreatment serum C-terminus of cytokeratin 19 (CYFRA21-1, CYFRA) status was evaluated in the patients with surgically treated esophageal squamous cell carcinoma.</p><p>Methods: A total of 1047 patients with surgically treated esophageal cancer were enrolled in a multi-institutional study promoted by the Japanese Esophageal Society. This study included an up-front surgery group (n = 412), a neoadjuvant chemotherapy (NAC) group (n = 486), and a neoadjuvant chemoradiation/radiation therapy (NACRT/RT) group (n = 149). The pretreatment CYFRA status was analyzed to assess prognostic significance using multivariate analysis according to treatment modalities.</p><p>Results: The CYFRA-positive group was significantly associated with deep tumor. Univariate analysis showed that the overall survival of the CYFRA-positive group was significantly worse than that of the CYFRA-negative group, but the difference was not significant in the multivariate analysis. CYFRA was an independent risk factor for poor prognosis just in the NACRT/RT group.</p><p>Conclusions: The CYFRA-positive group was associated with deep tumor and poor survival. Pretreatment CYFRA was not an independent risk factor for poor prognosis in the up-front surgery group or NAC group. It was an independent risk factor for poor prognosis just in the NACRT/RT group.</p>
収録刊行物
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- Annals of Thoracic and Cardiovascular Surgery
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Annals of Thoracic and Cardiovascular Surgery 28 (3), 163-170, 2022
Annals of Thoracic and Cardiovascular Surgery 編集委員会
