Glucocorticoid-induced redistribution lymphocytosis in mantle cell lymphoma with hyaline vascular Castleman disease-like features
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- Togitani Kazuto
- Department of Hematology, Kochi Medical School, Kochi University, Nankoku, Kochi, Japan,
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- Iguchi Mitsuko
- Department of Pathology, Kochi Medical School, Kochi University, Nankoku, Kochi, Japan,
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- Asagiri Tadashi
- Department of Laboratory Medicine, Kochi Medical School Hospital, Nankoku, Kochi, Japan
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- Ogasawara Fumiya
- Department of Hematology, Kochi Medical School, Kochi University, Nankoku, Kochi, Japan,
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- Murakami Ichiro
- Department of Pathology, Kochi Medical School, Kochi University, Nankoku, Kochi, Japan,
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- Kojima Kensuke
- Department of Hematology, Kochi Medical School, Kochi University, Nankoku, Kochi, Japan,
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Abstract
<p>We report a case of mantle cell lymphoma mimicking Castleman disease. A 76-year-old man presented with generalized lymphadenopathy, splenomegaly, anemia, polyclonal gammopathy, and pulmonary infiltrations. Lymph node biopsy revealed histological features of hyaline vascular Castleman disease. Treatment with prednisolone induced lymphocytosis with immunophenotypic and genetic features of mantle cell lymphoma. A detailed immunohistochemical study of the lymph node demonstrated a mantle cell lymphoma-mantle zone growth pattern. Glucocorticoid-induced distribution lymphocytosis has not been reported in mantle cell lymphoma. Careful observation of circulating lymphocytes during steroid treatment may enable diagnosis of the underlying occult lymphoma in a subset of patients exhibiting clinical manifestations of Castleman disease.</p>
Journal
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- Journal of Clinical and Experimental Hematopathology
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Journal of Clinical and Experimental Hematopathology 62 (1), 46-51, 2022
The Japanese Society for Lymphoreticular Tissue Research
