Survival benefit of supratotal resection in a long-term survivor of IDH-wildtype glioblastoma: a case report and literature review

• YAMAGUCHI Junya

  Department of Neurosurgery, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan

• MOTOMURA Kazuya

  Department of Neurosurgery, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan

• OHKA Fumiharu

  Department of Neurosurgery, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan

• AOKI Kosuke

  Department of Neurosurgery, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan

• TANAHASHI Kuniaki

  Department of Neurosurgery, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan

• HIRANO Masaki

  Department of Neurosurgery, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan

• CHALISE Lushun

  Department of Neurosurgery, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan

• NISHIKAWA Tomohide

  Department of Neurosurgery, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan

• SHIMIZU Hiroyuki

  Department of Neurosurgery, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan

• NATSUME Atsushi

  Department of Neurosurgery, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan

• WAKABAYASHI Toshihiko

  Department of Neurosurgery, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan

• SAITO Ryuta

  Department of Neurosurgery, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan

書誌事項

タイトル別名

• Survival Benefit of Supratotal Resection in a Long-term Survivor of <i>IDH</i>-wildtype Glioblastoma: A Case Report and Literature Review

抄録

Glioblastoma multiforme (GBM) is an aggressive cancer type, with fewer than 3–5% of patients surviving for more than 3 years. We describe a 48-year-old right-handed man who presented with generalized seizure attacks. Magnetic resonance imaging (MRI) revealed a heterogeneous gadolinium-enhancing lesion in the left inferior parietal lobule. The patient underwent awake surgery, and tumor resection included abnormalities on T2-weighted MRI, with subcortical mapping used to identify the deep functional boundaries. After supratotal resection, the tumor was diagnosed as GBM without isocitrate dehydrogenase (IDH) 1 and 2 mutations. At a follow-up evaluation, 9 years and 2 months after the surgery, the patient appeared healthy, and no relapse or recurrence was observed. We present the case of a long-term survivor of IDH-wildtype GBM. This case suggests that supratotal resection with intraoperative awake brain mapping can improve survival without impairing the patient’s neurological functions.

収録刊行物

• NMC Case Report Journal

  NMC Case Report Journal 8 (1), 747-753, 2021

  一般社団法人 日本脳神経外科学会

キーワード

• <i>IDH</i>-wildtype glioblastoma
• long-term survivor
• awake brain mapping
• supratotal resection

詳細情報

• CRID: 1390852870562873984
• NII論文ID: 130008113034
• DOI: 10.2176/nmccrj.cr.2021-0120
• ISSN: 21884226
• Web Site: https://www.jstage.jst.go.jp/article/nmccrj/8/1/8_cr.2021-0120/_pdf
• 本文言語コード: en
• データソース種別:
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  • Crossref
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  • KAKEN
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