Characteristics of Electrospray-Ionization Detection of Synthetic Di- to Penta-Oligopeptides by Amine Derivatizations

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  • SHEN Weilin
    Department of Bioscience and Biotechnology, Faculty of Agriculture, Graduate School of Kyushu University
  • ONO Kiyomi
    Department of Bioscience and Biotechnology, Faculty of Agriculture, Graduate School of Kyushu University
  • TANAKA Mitsuru
    Department of Bioscience and Biotechnology, Faculty of Agriculture, Graduate School of Kyushu University
  • MATSUI Toshiro
    Department of Bioscience and Biotechnology, Faculty of Agriculture, Graduate School of Kyushu University

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抄録

<p>Chemical derivatizations have been extensively developed for highly sensitive detection of bioactive small peptides; however, their advantages from the viewpoint of longer oligopeptides remain unverified. In this study, electrospray-ionization (ESI)–mass spectrometric (MS) detection of synthetic di- to pentapeptides consisting of glycine and sarcosine were characterized by four amine derivatization methods. It was concluded that the ESI-MS detection of di- to pentapeptides was characterized by the molecular surface area of derivatized peptide moieties with an optimal value of 250 – 300 Å2, regardless of hydrophobicity and derivatization methods.</p>

収録刊行物

  • Analytical Sciences

    Analytical Sciences 37 (11), 1629-1632, 2021-11-10

    社団法人 日本分析化学会

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