Urinary Isoxanthopterin in Heart Failure Patients

• Hori Masakazu

  Second Department of Internal Medicine, University of Toyama

• Imamura Teruhiko

  Second Department of Internal Medicine, University of Toyama

• Kataoka Naoya

  Second Department of Internal Medicine, University of Toyama

• Nakamura Makiko

  Second Department of Internal Medicine, University of Toyama

• Tanaka Shuhei

  Second Department of Internal Medicine, University of Toyama

• Onoda Hiroshi

  Second Department of Internal Medicine, University of Toyama

• Ushijima Ryuichi

  Second Department of Internal Medicine, University of Toyama

• Sobajima Mitsuo

  Second Department of Internal Medicine, University of Toyama

• Fukuda Nobuyuki

  Second Department of Internal Medicine, University of Toyama

• Ueno Hiroshi

  Second Department of Internal Medicine, University of Toyama

• Joho Shuji

  Second Department of Internal Medicine, University of Toyama

• Kinugawa Koichiro

  Second Department of Internal Medicine, University of Toyama

Abstract

Background:The prognostic impact of urinary isoxanthopterin (U-IXP), a recently proposed marker of oxidative stress, in patients with heart failure remains unknown. Methods and Results:Patients who were admitted to our institute for decompensated heart failure were prospectively included in the study; U-IXP was measured on admission. The association between the U-IXP concentration and a composite primary outcome that included cardiovascular death and heart failure readmissions following the index discharge was investigated. In all, 42 patients (median age 78 years [interquartile range {IQR} 69–85 years]; 25 males) were included in the study. The median U-IXP concentration on admission was 0.58 μmol/g creatinine (Cre; IQR 0.35–0.95 μmol/g Cre). A higher U-IXP concentration was an independent predictor of the primary outcome adjusted for clinical potential confounders and was associated with a significantly higher cumulative incidence of the primary outcome (71% vs. 16%, P=0.001) at a cut-off of 0.93 μmol/g Cre. Conclusions:U-IXP on admission was associated with cardiovascular death or heart failure readmission following the index discharge in patients with decompensated heart failure. The clinical implication of aggressive interventions to normalize U-IXP and the detailed prognostic mechanism of U-IXP in heart failure patients remain the next concerns.

Journal

• Circulation Reports

  Circulation Reports 3 (11), 654-659, 2021-11-10

  The Japanese Circulation Society

Keywords

• Congestion
• Hemodynamics
• Oxidative stress

Details

• CRID: 1390290006531078144
• NII Article ID: 130008115452
• DOI: 10.1253/circrep.cr-21-0112
• ISSN: 24340790
• Web Site: https://www.jstage.jst.go.jp/article/circrep/3/11/3_CR-21-0112/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2022208587
• Text Lang: en
• Data Source:
  • JaLC
  • Crossref
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed