Development of Novel Methodology Using Diazo Compounds and Metal Catalysts

• Harada Shingo

  Graduate School of Pharmaceutical Sciences, Chiba University

抄録

The ability to control the reactions of highly active chemical species to enable straightforward synthesis of valuable compounds such as bioactive natural products and pharmaceuticals is a continuing challenge in synthetic organic chemistry. This review describes the development of a methodology using reactive metal-carbene species and its synthetic application in our laboratory. First, regioselective synthesis of γ-amino acid equivalents to take advantage of their metal-dependent reactivities and the mechanistic rationale are presented. Chemoselective and enantioselective dearomatization reactions of several arenes with silver-carbene are also discussed. In the second half of the review, we discuss a carbene-insertion reaction into an amide and urea C–N bond for the assembly of nitrogen-bridged cyclic molecules.

収録刊行物

• ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ

  ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ 69 (12), 1170-1178, 2021-12-01

  公益社団法人 日本薬学会

キーワード

• carbene
• diazo compound
• silver
• rhodium
• catalyst

詳細情報

• CRID: 1390853188960247936
• NII論文ID: 130008123300
• NII書誌ID: AA00602100
• DOI: 10.1248/cpb.c21-00757
• ISSN: 13475223
• ISSN: 00092363
• NDL書誌ID: 031837525
• Web Site: http://id.ndl.go.jp/bib/031837525
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I031837525
• Web Site: https://www.jstage.jst.go.jp/article/cpb/69/12/69_c21-00757/_pdf
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
  • KAKEN
• 抄録ライセンスフラグ: 使用不可