Positive Lusitropic Effect of Quercetin on Isolated Ventricular Myocardia from Normal and Streptozotocin-Induced Diabetic Mice

• Hamaguchi Shogo

  Department of Pharmacology, Toho University Faculty of Pharmaceutical Sciences

• Abe Kohei

  Department of Pharmacology, Toho University Faculty of Pharmaceutical Sciences

• Komatsu Momoka

  Department of Pharmacology, Toho University Faculty of Pharmaceutical Sciences

• Kainuma Jun

  Department of Pharmacology, Toho University Faculty of Pharmaceutical Sciences

• Namekata Iyuki

  Department of Pharmacology, Toho University Faculty of Pharmaceutical Sciences

• Tanaka Hikaru

  Department of Pharmacology, Toho University Faculty of Pharmaceutical Sciences

抄録

The lusitropic effect of quercetin was examined on isolated ventricular myocardial tissue preparations from normal and streptozotocin-induced diabetic mice. The time required for 90% relaxation of the myocardium, which was prolonged in the diabetic mice, was shortened by quercetin in both normal and diabetic myocardia. This effect of quercetin was completely inhibited by cyclopiazonic acid but not by SEA0400. These results indicated that quercetin accelerates myocardial relaxation through activation of the sarco–endoplasmic reticulum Ca²⁺-ATPase.

収録刊行物

• Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ

  Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ 44 (12), 1894-1897, 2021-12-01

  公益社団法人 日本薬学会

キーワード

• quercetin
• myocardium
• lusitropy
• sarco–endoplasmic reticulum Ca²⁺-ATPase

詳細情報

• CRID: 1390008764027767424
• NII論文ID: 130008123499
• NII書誌ID: AA10885497
• DOI: 10.1248/bpb.b21-00580
• ISSN: 13475215
• ISSN: 09186158
• NDL書誌ID: 031837994
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I031837994
• Web Site: https://www.jstage.jst.go.jp/article/bpb/44/12/44_b21-00580/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2023019140
• 本文言語コード: en
• データソース種別:
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  • NDL
  • Crossref
  • CiNii Articles
  • KAKEN
• 抄録ライセンスフラグ: 使用不可