加齢によるタンパク質ホモキラリティーの破れ

• 藤井 紀子

  京都大学原子炉実験所

Abstract

Homochirality of proteins is essential for the development and maintenance of life. For a long time, it was considered that D-amino acids were excluded from living systems. However, recently D-aspartate (Asp) residues have been widely detected in proteins obtained from various tissues of elderly individuals. The presence of D-Asp in aged tissues of living organisms is a result of the spontaneous racemization of Asp residues during aging. This review deals with 1) the presence of D-Asp residues in protein of living tissues, 2) the mechanism of D-Asp formation in protein under physiological conditions, 3) the influence of D-Asp on protein structure and function 4) recent advances in D-amino acid analysis in protein.

Journal

• Viva Origino

  Viva Origino 44 (3), 7-, 2016

  The Society for the Study of the Origin and Evolution of Life Japan

Details

• CRID: 1390008832634367744
• NII Article ID: 130008124709
• DOI: 10.50968/vivaorigino.44_7
• ISSN: 13466933
• ISSN: 09104003
• Text Lang: ja
• Data Source:
  • JaLC
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Allowed