Study Profile of the Japan Multi-institutional Collaborative Cohort (J-MICC) Study

  • Takeuchi Kenji
    Department of Preventive Medicine, Nagoya University Graduate School of Medicine
  • Naito Mariko
    Department of Preventive Medicine, Nagoya University Graduate School of Medicine Department of Oral Epidemiology, Hiroshima University Graduate School of Biomedical and Health Sciences
  • Kawai Sayo
    Department of Preventive Medicine, Nagoya University Graduate School of Medicine Department of Public Health, Aichi Medical University School of Medicine
  • Tsukamoto Mineko
    Department of Preventive Medicine, Nagoya University Graduate School of Medicine
  • Kadomatsu Yuka
    Department of Preventive Medicine, Nagoya University Graduate School of Medicine
  • Kubo Yoko
    Department of Preventive Medicine, Nagoya University Graduate School of Medicine
  • Okada Rieko
    Department of Preventive Medicine, Nagoya University Graduate School of Medicine
  • Nagayoshi Mako
    Department of Preventive Medicine, Nagoya University Graduate School of Medicine
  • Tamura Takashi
    Department of Preventive Medicine, Nagoya University Graduate School of Medicine
  • Hishida Asahi
    Department of Preventive Medicine, Nagoya University Graduate School of Medicine
  • Nakatochi Masahiro
    Public Health Informatics Unit, Department of Integrated Health Sciences, Nagoya University Graduate School of Medicine
  • Sasakabe Tae
    Department of Preventive Medicine, Nagoya University Graduate School of Medicine Department of Public Health, Aichi Medical University School of Medicine
  • Hashimoto Shuji
    Department of Hygiene, Fujita Health University School of Medicine
  • Eguchi Hidetaka
    Diagnosis and Therapeutics of Intractable Diseases and Intractable Disease Research Center, Juntendo University Graduate School of Medicine
  • Momozawa Yukihide
    Laboratory for Genotyping Development, RIKEN Center for Integrative Medical Sciences
  • Ikezaki Hiroaki
    Department of Comprehensive General Internal Medicine, Kyushu University Graduate School, Faculty of Medical Sciences Department of General Internal Medicine, Kyushu University Hospital
  • Murata Masayuki
    Department of General Internal Medicine, Kyushu University Hospital
  • Furusyo Norihiro
    Department of Environmental Medicine and Infectious Diseases, Kyushu University Graduate School of Medical Sciences
  • Tanaka Keitaro
    Department of Preventive Medicine, Faculty of Medicine, Saga University
  • Hara Megumi
    Department of Preventive Medicine, Faculty of Medicine, Saga University
  • Nishida Yuichiro
    Department of Preventive Medicine, Faculty of Medicine, Saga University
  • Matsuo Keitaro
    Division of Cancer Epidemiology and Prevention, Aichi Cancer Center Research Institute Department of Cancer Epidemiology, Nagoya University Graduate School of Medicine
  • Ito Hidemi
    Division of Cancer Information and Control, Aichi Cancer Center Research Institute Department of Descriptive Cancer Epidemiology, Nagoya University Graduate School of Medicine
  • Oze Isao
    Division of Cancer Epidemiology and Prevention, Aichi Cancer Center Research Institute
  • Mikami Haruo
    Cancer Prevention Center, Chiba Cancer Center Research Institute
  • Nakamura Yohko
    Cancer Prevention Center, Chiba Cancer Center Research Institute
  • Kusakabe Miho
    Cancer Prevention Center, Chiba Cancer Center Research Institute
  • Takezaki Toshiro
    Department of International Island and Community Medicine, Kagoshima University Graduate School of Medical and Dental Sciences
  • Ibusuki Rie
    Department of International Island and Community Medicine, Kagoshima University Graduate School of Medical and Dental Sciences
  • Shimoshikiryo Ippei
    Department of International Island and Community Medicine, Kagoshima University Graduate School of Medical and Dental Sciences
  • Suzuki Sadao
    Department of Public Health, Nagoya City University Graduate School of Medical Sciences
  • Nishiyama Takeshi
    Department of Public Health, Nagoya City University Graduate School of Medical Sciences
  • Watanabe Miki
    Department of Public Health, Nagoya City University Graduate School of Medical Sciences
  • Koyama Teruhide
    Department of Epidemiology for Community Health and Medicine, Kyoto Prefectural University of Medicine
  • Ozaki Etsuko
    Department of Epidemiology for Community Health and Medicine, Kyoto Prefectural University of Medicine
  • Watanabe Isao
    Department of Epidemiology for Community Health and Medicine, Kyoto Prefectural University of Medicine
  • Kuriki Kiyonori
    Laboratory of Public Health, Division of Nutritional Sciences, School of Food and Nutritional Sciences, University of Shizuoka
  • Kita Yoshikuni
    Faculty of Nursing Science, Tsuruga Nursing University
  • Ueshima Hirotsugu
    Center for Epidemiologic Research in Asia, Shiga University of Medical Science
  • Matsui Kenji
    Division of Bioethics and Healthcare Law, The National Cancer Center Japan
  • Arisawa Kokichi
    Department of Preventive Medicine, Tokushima University Graduate School of Biomedical Sciences
  • Uemura Hirokazu
    Department of Preventive Medicine, Tokushima University Graduate School of Biomedical Sciences College of Nursing Art and Science, University of Hyogo
  • Katsuura-Kamano Sakurako
    Department of Preventive Medicine, Tokushima University Graduate School of Biomedical Sciences
  • Nakamura Sho
    Cancer Prevention and Control Division, Kanagawa Cancer Center Research Institute School of Health of Innovation, Kanagawa University of Human Services
  • Narimatsu Hiroto
    Cancer Prevention and Control Division, Kanagawa Cancer Center Research Institute School of Health of Innovation, Kanagawa University of Human Services
  • Hamajima Nobuyuki
    Department of Healthcare Administration, Nagoya University Graduate School of Medicine
  • Tanaka Hideo
    Shiga University of Medical Science
  • Wakai Kenji
    Department of Preventive Medicine, Nagoya University Graduate School of Medicine

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Abstract

<p>Background: The Japan Multi-institutional Collaborative Cohort (J-MICC) study was launched in 2005 to examine gene–environment interactions in lifestyle-related diseases, including cancers, among the Japanese. This report describes the study design and baseline profile of the study participants.</p><p>Methods: The participants of the J-MICC Study were individuals aged 35 to 69 years enrolled from respondents to study announcements in specified regions, inhabitants attending health checkup examinations provided by local governments, visitors at health checkup centers, and first-visit patients at a cancer hospital in Japan. At the time of the baseline survey, from 2005 to 2014, we obtained comprehensive information regarding demographics, education, alcohol consumption, smoking, sleeping, exercise, food intake frequency, medication and supplement use, personal and family disease history, psychological stress, and female reproductive history and collected peripheral blood samples.</p><p>Results: The baseline survey included 92,610 adults (mean age: 55.2 [standard deviation, 9.4] years, 44.1% men) from 14 study regions in 12 prefectures. The participation rate was 33.5%, with participation ranging from 19.7% to 69.8% in different study regions. The largest number of participants was in the age groups of 65–69 years for men and 60–64 years for women. There were differences in body mass index, educational attainment, alcohol consumption, smoking, and sleep duration between men and women.</p><p>Conclusions: The J-MICC Study collected lifestyle and clinical data and biospecimens from over 90,000 participants. This cohort is expected to be a valuable resource for the national and international scientific community in providing evidence to support longer healthy lives.</p>

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