Tumor microenvironment of adult T-cell leukemia/lymphoma
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- Takeuchi Mai
- Department of Pathology, Kurume University, Kurume, Fukuoka, Japan
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- Miyoshi Hiroaki
- Department of Pathology, Kurume University, Kurume, Fukuoka, Japan
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- Ohshima Koichi
- Department of Pathology, Kurume University, Kurume, Fukuoka, Japan
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Abstract
<p>Adult T-cell leukemia/lymphoma (ATLL) is a malignancy caused by the human T-cell leukemia virus type 1. Aggressive ATLL is refractory to conventional chemotherapy and has a poor prognosis. Better therapeutic approaches, including cancer immunotherapy, are required to improve survival and prognosis. The genetic landscape of ATLL reveals frequent genetic alterations in genes associated with immune surveillance, including major histocompatibility complex (MHC) class I, CD58 antigen, and programmed cell death ligand 1. Clinicopathological investigations also revealed tumor immunity mechanisms in ATLL, including immune checkpoint molecules, MHC molecules, tumor-associated macrophages, and chemokines. However, the tumor microenvironment of ATLL remains complex because ATLL itself originates from T-cells, usually expressing regulatory T-cell markers. In this review, we discuss the recent literature describing the tumor microenvironment of ATLL.</p>
Journal
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- Journal of Clinical and Experimental Hematopathology
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Journal of Clinical and Experimental Hematopathology 61 (4), 202-209, 2021
The Japanese Society for Lymphoreticular Tissue Research
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Keywords
Details 詳細情報について
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- CRID
- 1390009018101246080
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- NII Article ID
- 130008131906
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- ISSN
- 18809952
- 13464280
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- Text Lang
- en
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- Data Source
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- JaLC
- Crossref
- CiNii Articles
- KAKEN
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- Abstract License Flag
- Disallowed