Significance of trogocytosis and exosome-mediated transport in establishing and maintaining the tumor microenvironment in lymphoid malignancies

• Kawashima Masaharu

  Department of Hematological Malignancy, Institute of Medical Science, Tokai University, Isehara, Kanagawa, Japan, Division of Clinical Oncology and Hematology, The Jikei University School of Medicine, Minato-ku, Tokyo, Japan,

• Higuchi Hiroshi

  Department of Hematological Malignancy, Institute of Medical Science, Tokai University, Isehara, Kanagawa, Japan, Center for Cancer Immunology and Cutaneous Biology Research Center, Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA

• Kotani Ai

  Department of Hematological Malignancy, Institute of Medical Science, Tokai University, Isehara, Kanagawa, Japan,

Abstract

It is widely accepted that the tumor microenvironment plays an important role in the progression of lymphoid malignancies. Interaction between the tumor and its surrounding immune cells is considered a potential therapeutic target. For example, anti-programmed cell death 1 (PD-1) antibody stimulates the surrounding exhausted immune cells to release PD-1/PD-L1, thereby leading to the regression of PD-L1-positive tumors. Recently, biological phenomena, such as trogocytosis and exosome-mediated transport were demonstrated to be involved in establishing and maintaining the tumor microenvironment. We found that trogocytosis-mediated PD-L1/L2 transfer from tumor cells to monocytes/macrophages is involved in immune dysfunction in classic Hodgkin lymphoma. Exosomes derived from Epstein-Barr virus (EBV)-associated lymphoma cells induce lymphoma tumorigenesis by transferring the EBV-coding microRNAs from the infected cells to macrophages. In this review, we summarized these biological phenomena based on our findings.

Journal

• Journal of Clinical and Experimental Hematopathology

  Journal of Clinical and Experimental Hematopathology 61 (4), 192-201, 2021

  The Japanese Society for Lymphoreticular Tissue Research

Keywords

• Exosome
• lymphoid malignancy
• trogocytosis
• tumor microenvironment

Details

• CRID: 1390571968052967808
• NII Article ID: 130008131967
• DOI: 10.3960/jslrt.21005
• ISSN: 18809952
• ISSN: 13464280
• PubMed: 34193756
• Web Site: https://www.jstage.jst.go.jp/article/jslrt/61/4/61_21005/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2023054344
• Text Lang: en
• Data Source:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed