Proteomic Analysis of Cerebrospinal Fluid Following Remote Ischemic Preconditioning to Identify Therapeutic Targets for Perioperative Neurocognitive Disorders

DOI Open Access
  • Nakamori Yuki
    Department of Molecular Pathobiology and Cell Adhesion Biology, Mie University Graduate School of Medicine

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Other Title
  • Remote Ischemic Preconditioning に伴う 脳脊髄液プロテオーム変動の解析による 周術期神経認知障害治療標的の探索

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Abstract

 Perioperative Neurocognitive Disorder (PND), including Postoperative Delirium and Postoperative Cognitive Dysfunction, which are triggered by general anesthesia and surgical invasion, have a negative impact on postoperative hospital stay and survival. As the indications for surgery in the elderly are expanding, prevention of PND is an urgent issue in perioperative management from the viewpoint of medical economy. <br> In this study, we hypothesized that the proteomic changes of myokine in cerebrospinal fluid (CSF) caused by Remote Ischemic Preconditioning (RIPC) would have a protective effect on the brain and used SWATH (sequential window acquisition of all theoretical fragment ion spectra) method to analyze time series specimens. The results revealed that FNDC5 and SPARC, two representative myokines, had significantly increased in CSF one hour after RIPC. The muscle-brain crosstalk induced by these myokines might be the core of the brain protective effect of RIPC.

Journal

  • CIRCULATION CONTROL

    CIRCULATION CONTROL 42 (2), 92-99, 2021

    Japan Society of Circulation Control in Medicine

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