Antiviral Susceptibilities of Avian Influenza A(H5), A(H7), and A(H9) Viruses Isolated in Japan

DOI Web Site Web Site PubMed 参考文献14件 オープンアクセス
  • Takashita Emi
    Research Center for Influenza and Respiratory Viruses, National Institute of Infectious Diseases, Japan
  • Morita Hiroko
    Research Center for Influenza and Respiratory Viruses, National Institute of Infectious Diseases, Japan
  • Nagata Shiho
    Research Center for Influenza and Respiratory Viruses, National Institute of Infectious Diseases, Japan
  • Shirakura Masayuki
    Research Center for Influenza and Respiratory Viruses, National Institute of Infectious Diseases, Japan
  • Fujisaki Seiichiro
    Research Center for Influenza and Respiratory Viruses, National Institute of Infectious Diseases, Japan
  • Miura Hideka
    Research Center for Influenza and Respiratory Viruses, National Institute of Infectious Diseases, Japan
  • Takayama Ikuyo
    Research Center for Influenza and Respiratory Viruses, National Institute of Infectious Diseases, Japan
  • Arita Tomoko
    Research Center for Influenza and Respiratory Viruses, National Institute of Infectious Diseases, Japan
  • Suzuki Yasushi
    Research Center for Influenza and Respiratory Viruses, National Institute of Infectious Diseases, Japan
  • Yamaoka Masaoki
    Hyogo Prefectural Institute of Public Health Science, Japan
  • Tanikawa Taichiro
    Virus group, Division of Infectious Animal Disease Research, National Institute of Animal Health, National Agriculture and Food Research Organization, Japan
  • Tsunekuni Ryota
    Emerging Virus Group, Division of Zoonosis Research, National Institute of Animal Health, National Agriculture and Food Research Organization, Japan
  • Mine Junki
    Emerging Virus Group, Division of Zoonosis Research, National Institute of Animal Health, National Agriculture and Food Research Organization, Japan
  • Sakuma Saki
    Emerging Virus Group, Division of Zoonosis Research, National Institute of Animal Health, National Agriculture and Food Research Organization, Japan
  • Uchida Yuko
    Emerging Virus Group, Division of Zoonosis Research, National Institute of Animal Health, National Agriculture and Food Research Organization, Japan
  • Shibata Akihiro
    Animal Quarantine Service, Ministry of Agriculture, Forestry and Fisheries, Japan
  • Iwanaka Mari
    Animal Quarantine Service, Ministry of Agriculture, Forestry and Fisheries, Japan
  • Kishida Noriko
    Research Center for Influenza and Respiratory Viruses, National Institute of Infectious Diseases, Japan
  • Nakamura Kazuya
    Research Center for Influenza and Respiratory Viruses, National Institute of Infectious Diseases, Japan
  • Kageyama Tsutomu
    Research Center for Influenza and Respiratory Viruses, National Institute of Infectious Diseases, Japan
  • Watanabe Shinji
    Research Center for Influenza and Respiratory Viruses, National Institute of Infectious Diseases, Japan
  • Hasegawa Hideki
    Research Center for Influenza and Respiratory Viruses, National Institute of Infectious Diseases, Japan
  • The Influenza Virus Surveillance Group of Japan

この論文をさがす

抄録

<p>The circulation of avian influenza A viruses in poultry is a public health concern due to the potential transmissibility and severity of these viral infections. Monitoring the susceptibility of these viruses to antivirals is important for developing measures to strengthen the level of preparedness against influenza pandemics. However, drug susceptibility information on these viruses is limited. Here, we determined the susceptibilities of avian influenza A(H5N1), A(H5N2), A(H5N8), A(H7N7), A(H7N9), A(H9N1), and A(H9N2) viruses isolated in Japan to the antivirals approved for use there: an M2 inhibitor (amantadine), neuraminidase inhibitors (oseltamivir, peramivir, zanamivir, and laninamivir) and RNA polymerase inhibitors (baloxavir and favipiravir). Genotypic methods that detect amino acid substitutions associated with antiviral resistance and phenotypic methods that assess phenotypic viral susceptibility to drugs have revealed that these avian influenza A viruses are susceptible to neuraminidase and RNA polymerase inhibitors. These results suggest that neuraminidase and RNA polymerase inhibitors currently approved in Japan could be a treatment option against influenza A virus infections in humans.</p>

収録刊行物

参考文献 (14)*注記

もっと見る

関連プロジェクト

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ