Antiviral Susceptibilities of Avian Influenza A(H5), A(H7), and A(H9) Viruses Isolated in Japan
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- Takashita Emi
- Research Center for Influenza and Respiratory Viruses, National Institute of Infectious Diseases, Japan
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- Morita Hiroko
- Research Center for Influenza and Respiratory Viruses, National Institute of Infectious Diseases, Japan
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- Nagata Shiho
- Research Center for Influenza and Respiratory Viruses, National Institute of Infectious Diseases, Japan
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- Shirakura Masayuki
- Research Center for Influenza and Respiratory Viruses, National Institute of Infectious Diseases, Japan
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- Fujisaki Seiichiro
- Research Center for Influenza and Respiratory Viruses, National Institute of Infectious Diseases, Japan
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- Miura Hideka
- Research Center for Influenza and Respiratory Viruses, National Institute of Infectious Diseases, Japan
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- Takayama Ikuyo
- Research Center for Influenza and Respiratory Viruses, National Institute of Infectious Diseases, Japan
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- Arita Tomoko
- Research Center for Influenza and Respiratory Viruses, National Institute of Infectious Diseases, Japan
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- Suzuki Yasushi
- Research Center for Influenza and Respiratory Viruses, National Institute of Infectious Diseases, Japan
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- Yamaoka Masaoki
- Hyogo Prefectural Institute of Public Health Science, Japan
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- Tanikawa Taichiro
- Virus group, Division of Infectious Animal Disease Research, National Institute of Animal Health, National Agriculture and Food Research Organization, Japan
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- Tsunekuni Ryota
- Emerging Virus Group, Division of Zoonosis Research, National Institute of Animal Health, National Agriculture and Food Research Organization, Japan
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- Mine Junki
- Emerging Virus Group, Division of Zoonosis Research, National Institute of Animal Health, National Agriculture and Food Research Organization, Japan
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- Sakuma Saki
- Emerging Virus Group, Division of Zoonosis Research, National Institute of Animal Health, National Agriculture and Food Research Organization, Japan
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- Uchida Yuko
- Emerging Virus Group, Division of Zoonosis Research, National Institute of Animal Health, National Agriculture and Food Research Organization, Japan
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- Shibata Akihiro
- Animal Quarantine Service, Ministry of Agriculture, Forestry and Fisheries, Japan
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- Iwanaka Mari
- Animal Quarantine Service, Ministry of Agriculture, Forestry and Fisheries, Japan
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- Kishida Noriko
- Research Center for Influenza and Respiratory Viruses, National Institute of Infectious Diseases, Japan
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- Nakamura Kazuya
- Research Center for Influenza and Respiratory Viruses, National Institute of Infectious Diseases, Japan
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- Kageyama Tsutomu
- Research Center for Influenza and Respiratory Viruses, National Institute of Infectious Diseases, Japan
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- Watanabe Shinji
- Research Center for Influenza and Respiratory Viruses, National Institute of Infectious Diseases, Japan
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- Hasegawa Hideki
- Research Center for Influenza and Respiratory Viruses, National Institute of Infectious Diseases, Japan
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Abstract
<p>The circulation of avian influenza A viruses in poultry is a public health concern due to the potential transmissibility and severity of these viral infections. Monitoring the susceptibility of these viruses to antivirals is important for developing measures to strengthen the level of preparedness against influenza pandemics. However, drug susceptibility information on these viruses is limited. Here, we determined the susceptibilities of avian influenza A(H5N1), A(H5N2), A(H5N8), A(H7N7), A(H7N9), A(H9N1), and A(H9N2) viruses isolated in Japan to the antivirals approved for use there: an M2 inhibitor (amantadine), neuraminidase inhibitors (oseltamivir, peramivir, zanamivir, and laninamivir) and RNA polymerase inhibitors (baloxavir and favipiravir). Genotypic methods that detect amino acid substitutions associated with antiviral resistance and phenotypic methods that assess phenotypic viral susceptibility to drugs have revealed that these avian influenza A viruses are susceptible to neuraminidase and RNA polymerase inhibitors. These results suggest that neuraminidase and RNA polymerase inhibitors currently approved in Japan could be a treatment option against influenza A virus infections in humans.</p>
Journal
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- Japanese Journal of Infectious Diseases
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Japanese Journal of Infectious Diseases 75 (4), 398-402, 2022-07-31
National Institute of Infectious Diseases, Japanese Journal of Infectious Diseases Editorial Committee
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Details 詳細情報について
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- CRID
- 1390292815260673536
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- NII Article ID
- 130008136488
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- NII Book ID
- AA1132885X
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- ISSN
- 18842836
- 13446304
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- NDL BIB ID
- 032300806
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- PubMed
- 34980710
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
- KAKEN
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- Abstract License Flag
- Disallowed