Neural tube closure and embryonic metabolism
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- Yoshifumi Yamaguchi
- Department of Genetics, Graduate School of Pharmaceutical Sciences The University of Tokyo Tokyo Japan
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- Hidenobu Miyazawa
- Department of Genetics, Graduate School of Pharmaceutical Sciences The University of Tokyo Tokyo Japan
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- Masayuki Miura
- Department of Genetics, Graduate School of Pharmaceutical Sciences The University of Tokyo Tokyo Japan
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Abstract
Abstract Neural tube closure (NTC) is an embryonic process during formation of the mammalian central nervous system. Disruption of the dynamic, sequential events of NTC can cause neural tube defects (NTD) leading to spina bifida and anencephaly in the newborn. NTC is affected by inherent factors such as genetic mutation or if the mother is exposed to certain environmental factors such as intake of harmful chemicals, maternal infection, irradiation, malnutrition, and inadequate or excessive intake of specific nutrients. Although effects of these stress factors on NTC have been intensively studied, the metabolic state of a normally developing embryo remains unclear. State-of-the art mass spectrometry techniques have enabled detailed study of embryonic metabolite profiles and their distribution within tissues. This approach has demonstrated that glucose metabolism is altered during NTC stages involving chorioallantoic branching. An understanding of embryonic metabolic rewiring would help reveal the etiology of NTD caused by environmental factors.
Journal
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- official journal of Congeital Anomalies Research Association of Japan
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official journal of Congeital Anomalies Research Association of Japan 57 (5), 134-137, 2017
The Japanese Teratology Society
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Keywords
Details 詳細情報について
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- CRID
- 1390572244918899072
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- NII Article ID
- 130008142315
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- ISSN
- 24331503
- 17414520
- 00372285
- 09143505
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- Web Site
- https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fcga.12219
- https://onlinelibrary.wiley.com/doi/pdf/10.1111/cga.12219
- https://onlinelibrary.wiley.com/doi/full-xml/10.1111/cga.12219
- https://onlinelibrary.wiley.com/doi/am-pdf/10.1111/cga.12219
- https://search.jamas.or.jp/link/ui/2018287665
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- Text Lang
- en
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- Data Source
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- JaLC
- Crossref
- CiNii Articles
- KAKEN
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- Abstract License Flag
- Disallowed