EOGTが触媒する<i>O</i>-GlcNAc修飾
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- Lo Pei-Wen
- Department of Molecular Biochemistry, Nagoya University Graduate School of Medicine
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- Okajima Tetsuya
- Department of Molecular Biochemistry, Nagoya University Graduate School of Medicine Institute for Glyco-core Research (iGCORE), Nagoya University
書誌事項
- タイトル別名
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- Eogt-catalyzed <i>O</i>-GlcNAcylation
- Eogt-catalyzed O-GlcNAcylation
- EOGTが触媒するO-GlcNAc修飾
- EOGT ガ ショクバイ スル O-GlcNAc シュウショク
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抄録
<p>O-GlcNAcylation is critical in human physiology. The dysregulation of O-GlcNAcylation on various intracellular proteins impacts cardiovascular diseases, the immune system, type 2 diabetes, neurodegeneration diseases, and cancers. In the past decade, extracellular O-GlcNAcylation was discovered from the conserved epidermal growth factor-like (EGF) domain in Drosophila and mammals. Extracellular O-GlcNAcylation is catalyzed by EGF domain O-GlcNAc transferase (EOGT) in the endoplasmic reticulum, and, unlike intracellular O-GlcNAcylation, it is further elongated with galactose and sialic acid in the Golgi apparatus. In this review, we retrospect the studies addressing the catalysis of EOGT, the conserved consensus sequence, the impacts of abnormal extracellular O-GlcNAcylation, and the diseases related to EOGT mutation.</p>
収録刊行物
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- Trends in Glycoscience and Glycotechnology
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Trends in Glycoscience and Glycotechnology 34 (197), E1-E6, 2022-01-25
FCCA(Forum: Carbohydrates Coming of Age)
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詳細情報 詳細情報について
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- CRID
- 1390290846626524800
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- NII論文ID
- 130008144175
- 130008144174
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- NII書誌ID
- AA10995236
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- ISSN
- 18832113
- 09157352
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- CiNii Articles
- KAKEN
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- 抄録ライセンスフラグ
- 使用不可