Prevalence of inhaled allergen-specific IgE antibody positivity in the healthy Japanese population

• Tanaka Jun

  Division of Pulmonary Medicine, Department of Medicine, Tokai University School of Medicine Clinical Research Center, National Hospital Organization Sagamihara National Hospital

• Fukutomi Yuma

  Clinical Research Center, National Hospital Organization Sagamihara National Hospital

• Shiraishi Yoshiki

  Division of Pulmonary Medicine, Department of Medicine, Tokai University School of Medicine

• Kitahara Asako

  Division of Pulmonary Medicine, Department of Medicine, Tokai University School of Medicine

• Oguma Tsuyoshi

  Division of Pulmonary Medicine, Department of Medicine, Tokai University School of Medicine

• Hamada Yuto

  Clinical Research Center, National Hospital Organization Sagamihara National Hospital

• Watai Kentaro

  Clinical Research Center, National Hospital Organization Sagamihara National Hospital

• Nagai Tadashi

  Central Blood Institute, Japanese Red Cross Society

• Taniguchi Masami

  Clinical Research Center, National Hospital Organization Sagamihara National Hospital Shonan Kamakura General Hospital Center for Immunology and Allergology

• Asano Koichiro

  Division of Pulmonary Medicine, Department of Medicine, Tokai University School of Medicine

Abstract

Background: Measurement of allergen-specific IgE antibodies to inhaled allergens is important for the diagnosis and risk evaluation of allergic diseases such as asthma and allergic rhinitis. This study aimed to elucidate the prevalence of allergen sensitization among the healthy population in Japan using serum samples stocked in the Japanese Red Cross for blood donation. Methods: Age- and gender-stratified serum samples (n = 800) from residents in Tokyo aged 20-59 years were randomly selected from the stocked serum obtained for blood donation in 2005. Total and specific IgE antibodies to 17 inhaled allergens were measured by the ImmunoCAP method. Individuals with positive (≥0.35 U_A/mL) specific IgE antibodies to at least one inhaled allergen were defined as atopic. Stocked serums from donors aged 20-29 years in Sapporo, Osaka, Fukuoka, and Okinawa (n = 200 each) were also obtained for the measurement of IgE to six common inhaled allergens, to evaluate regional differences in the rate of positivity. Results: Among residents in Tokyo, the prevalence of atopy was 78.0% and highest in men aged 20-29 years (94.0%), which decreased with age. The prevalence of specific IgE antibodies was highest for Japanese cedar pollen (66.8%), followed by cypress pollen (46.8%), Dermatophagoides pteronyssinus (38.3%), and moths (30.1%). Examination of IgE to Japanese cedar pollen, D. pteronyssinus, and moths identified 97.6% of atopic subjects in Tokyo. There were substantial regional differences in the prevalence of pollen IgE positivity. Conclusions: This study demonstrated an extremely high prevalence of positivity in inhaled allergen-specific IgE antibodies among healthy adults in Japan.

Journal

• Allergology International

  Allergology International 71 (1), 117-124, 2022

  Japanese Society of Allergology

Keywords

• Epidemiology
• Healthy population
• Inhaled allergen
• Sensitization
• Specific IgE antibodies

Details

• CRID: 1390290868759953536
• NII Article ID: 130008145218
• DOI: 10.1016/j.alit.2021.08.009
• ISSN: 14401592
• ISSN: 13238930
• Web Site: https://api.elsevier.com/content/article/PII:S132389302100099X?httpAccept=text/xml
• Web Site: https://api.elsevier.com/content/article/PII:S132389302100099X?httpAccept=text/plain
• Web Site: https://search.jamas.or.jp/link/ui/2023078930
• Text Lang: en
• Data Source:
  • JaLC
  • Crossref
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed