Exercise Capacity and Frailty Are Associated with Cerebral White Matter Hyperintensity in Older Adults with Cardiovascular Disease

• Hirashiki Akihiro

  Department of Cardiology, National Center for Geriatrics and Gerontology

• Shimizu Atsuya

  Department of Cardiology, National Center for Geriatrics and Gerontology

• Suzuki Noriyuki

  Department of Cardiology, National Center for Geriatrics and Gerontology

• Nomoto Kenichiro

  Department of Cardiology, National Center for Geriatrics and Gerontology

• Kokubo Manabu

  Department of Cardiology, National Center for Geriatrics and Gerontology

• Sugimoto Taiki

  Center for Comprehensive Care and Research on Memory Disorders, National Center for Geriatrics and Gerontology

• Hashimoto Kakeru

  Department of Rehabilitation, National Center for Geriatrics and Gerontology

• Sato Kenji

  Department of Rehabilitation, National Center for Geriatrics and Gerontology

• Sakurai Takashi

  Center for Comprehensive Care and Research on Memory Disorders, National Center for Geriatrics and Gerontology

• Murohara Toyoaki

  Department of Cardiology, Nagoya University Graduate School of Medicine

• Washimi Yukihiko

  Department of Geriatrics and Gerontology, National Center for Geriatrics and Gerontology

• Arai Hidenori

  Department of Geriatrics and Gerontology, National Center for Geriatrics and Gerontology

抄録

Cerebral white matter hyperintensity (WMH) is highly prevalent among older adults. There is little information about the relationship among WMH extent, frailty status, and exercise capacity in older adults with cardiovascular disease (CVD). We assessed the association of WMH with frailty and exercise capacity in CVD patients. Seventy-eight stable older adults with CVD were evaluated for WMH, the Kihon Checklist (KCL), short physical performance battery score (SPPB), and cardiopulmonary exercise testing. WMH volume was quantified on brain magnetic resonance imaging. Patients were classified into 3 groups (using tertiles of 0.52% and 1.05%) according to WMH as a percentage of intracranial volume (ICV), and their KCL scores and exercise capacities were compared. The 3 WMH/ICV groups were mild (n = 26, 0.26% ± 0.14% of intracranial volume), moderate (n = 26, 0.70% ± 0.15%), and severe (n = 26, 1.75% ± 0.67%). Peak VO₂ was 15.2 ± 3.7 mL kg⁻¹ minute⁻¹ (mild group), 12.9 ± 3.5 mL kg⁻¹ min⁻¹ (moderate), and 11.4 ± 2.3 mL kg⁻¹ minute⁻¹ (severe) (mild versus moderate, P = 0.049; mild versus severe, P = 0.001). Multivariate regression analysis showed significant associations of severe WMH/ICV with peak VO₂ and SPPB. Cerebral WMH was strongly negatively associated with SPPB and peak VO₂. WMH volume may be related to exercise capacity and frailty in stable older adult patients with CVD.

収録刊行物

• International Heart Journal

  International Heart Journal 63 (1), 77-84, 2022-01-29

  一般社団法人 インターナショナル・ハート・ジャーナル刊行会

キーワード

• Cardiopulmonary exercise testing
• Cerebral small vessel disease
• Physical frailty

詳細情報

• CRID: 1390009454814842112
• NII論文ID: 130008145714
• DOI: 10.1536/ihj.21-377
• ISSN: 13493299
• ISSN: 13492365
• Web Site: https://www.jstage.jst.go.jp/article/ihj/63/1/63_21-377/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2023032728
• 本文言語コード: en
• データソース種別:
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  • Crossref
  • CiNii Articles
  • KAKEN
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