Autograft of Demineralized Dentin Matrix Prepared Immediately after Extraction for Horizontal Bone Augmentation of the Anterior Atrophic Maxilla: A First Case of Non-Vital Tooth-Derived Dentin

DOI Web Site Web Site 1 Citations 27 References Open Access
  • Okubo Naoto
    Laboratory of Molecular and Cellular Medicine, Faculty of Pharmaceutical Sciences, Hokkaido University
  • Ishikawa Masahiro
    Ishikawa Dental Clinic
  • Shakya Mamata
    Division of Oral Regenerative Medicine, School of Dentistry, Health Sciences University of Hokkaido
  • Hosono Hidetaka
    DeVine Inc.
  • Maehara Osamu
    Laboratory of Molecular and Cellular Medicine, Faculty of Pharmaceutical Sciences, Hokkaido University
  • Ohkawara Tatsuya
    Laboratory of Molecular and Cellular Medicine, Faculty of Pharmaceutical Sciences, Hokkaido University
  • Ohnishi Shunsuke
    Laboratory of Molecular and Cellular Medicine, Faculty of Pharmaceutical Sciences, Hokkaido University
  • Akazawa Toshiyuki
    Industrial Technology and Environment Research Development, Hokkaido Research Organization
  • Murata Masaru
    Division of Oral Regenerative Medicine, School of Dentistry, Health Sciences University of Hokkaido

Search this article

Abstract

<p>Onlay bone augmentation is a challenging field, especially in esthetic zones. In implant dentistry, labial bone loss is generally recovered through autologous bone and/or biomaterials. Dental pioneers have been applying a patient-own demineralized dentin matrix (DDM) for bone regeneration. The aim of this study was to histologically and radiologically evaluate horizontal bone augmentation on an anterior atrophic maxilla using an autograft of non-vital tooth-derived DDM for implant. A 56-year-old female patient presented with severe labial bone loss. Autologous DDM was immediately prepared for horizontal ridge augmentation. DDM blocks were fixed with titanium screws for lateral augmentation. DDM granules were grafted on the atrophic bone between the DDM blocks. Twelve months postoperatively, bone biopsy was performed from the implant placement point for histological observation. X-ray computed tomography (CT) was performed before and after the DDM graft surgery. Hematoxylin and eosin sections showed that new bones were directly generated on the DDM residue. CT images showed the original buccal bone lines and root-type and wall-type DDM. The grafted DDMs were clearly found on the original bone. The outlines in the 22nd region indicated an 8.11 mm horizontal width after the implant placements compared to 4.95 mm before the augmentation. Additionally, the width at the upper level increased from 3.38 mm to 5.92 mm. DDM scaffolds contributed to the horizontal bony support required to place the implants. The patient experienced therapeutic success with DDM immediate autograft and implant surgery.</p>

Journal

Citations (1)*help

See more

References(27)*help

See more

Related Projects

See more

Keywords

Details 詳細情報について

Report a problem

Back to top