Docosahexaenoic Acid Selectively Suppresses U46619- and PGF<sub>2α</sub>-Induced Contractions in Guinea Pig Tracheal Smooth Muscles
-
- Obara Keisuke
- Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Toho University
-
- Inaba Rikako
- Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Toho University
-
- Kawakita Mirai
- Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Toho University
-
- De Dios Regadera Montserrat
- Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Toho University
-
- Uetake Tomomi
- Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Toho University
-
- Murata Azusa
- Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Toho University
-
- Nishioka Nanako
- Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Toho University
-
- Kuroki Kota
- Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Toho University
-
- Yoshioka Kento
- Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Toho University
-
- Tanaka Yoshio
- Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Toho University
この論文をさがす
抄録
<p>We investigated the potential inhibitory effects of docosahexaenoic acid (DHA) on the contractions of guinea pig tracheal smooth muscles in response to U46619 (a thromboxane A2 (TXA2) mimetic) and prostaglandin F2α (PGF2α) to examine whether this n-3 polyunsaturated fatty acid suppresses prostanoid-induced tracheal contractions. DHA (3 × 10−5 M) significantly suppressed tracheal contractions elicited by lower concentrations of U46619 (10−8 M) and PGF2α (5 × 10−7 M) (vs. control), although it did not suppress the contractions induced by higher concentrations (U46619: 10−7 M; PGF2α: 10−5 M). Supporting these findings, DHA (4 × 10−5 M/6 × 10−5 M) shifted the concentration-response curves for U46619 (10−9–10−6 M) and PGF2α (10−8–10−5 M) to the right. However, the slope of the regression line in the Schild plot of DHA vs. U46619/PGF2α was larger than unity. The tracheal contractions induced by U46619 (10−8 M) and PGF2α (5 × 10−7 M) were significantly suppressed by the prostanoid TP receptor antagonist SQ 29,548 (10−6 M) (vs. ethanol-treated). In contrast, DHA (4 × 10−5 M) did not show significant inhibitory effects on the contractions induced by acetylcholine (10−8–10−4 M), histamine (10−8–10−4 M), and leukotriene D4 (10−11–10−7 M) (vs. ethanol-treated). These findings indicate that DHA selectively suppresses tracheal contractions induced by U46619 and PGF2α. Therefore, DHA may be a useful therapeutic agent against asthma associated with tracheal/bronchial hyper-constriction caused by prostanoids including TXA2 and PGF2α.</p>
収録刊行物
-
- Biological & Pharmaceutical Bulletin
-
Biological & Pharmaceutical Bulletin 45 (2), 240-244, 2022-02-01
公益社団法人 日本薬学会
- Tweet
キーワード
詳細情報 詳細情報について
-
- CRID
- 1390853879739828352
-
- NII論文ID
- 130008150259
-
- ISSN
- 13475215
- 09186158
-
- 本文言語コード
- en
-
- データソース種別
-
- JaLC
- Crossref
- CiNii Articles
- KAKEN
-
- 抄録ライセンスフラグ
- 使用不可