Epigenetics and burning mouth syndrome

DOI
  • Abiko Yoshihiro
    Division of Oral Medicine and Pathology, Department of Human Biology and Pathophysiology, School of Dentistry, Health Sciences University of Hokkaido
  • Matsuoka Hirofumi
    Division of Disease Control and Molecular Epidemiology, Department of Oral Growth and Development, School of Dentistry, Health Sciences University of Hokkaido
  • Uehara Osamu
    Division of Disease Control and Molecular Epidemiology, Department of Oral Growth and Development, School of Dentistry, Health Sciences University of Hokkaido
  • Yoshida Koki
    Division of Oral Medicine and Pathology, Department of Human Biology and Pathophysiology, School of Dentistry, Health Sciences University of Hokkaido
  • Miura Hiroko
    Division of Disease Control and Molecular Epidemiology, Department of Oral Growth and Development, School of Dentistry, Health Sciences University of Hokkaido
  • Moriya Mitsuru
    Department of Psychosomatic Internal Medicine, Health Sciences University of Hokkaido Hospital
  • Toyofuku Akira
    Department of Psychosomatic Dentistry, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University

Bibliographic Information

Other Title
  • エピジェネティクスとBurning mouth syndrome
  • ―Epigenetics alteration involved in the pathogenesis of burning mouth syndrome―
  • ―Burning mouth syndromeの病態への関与が疑われるエピジェネティクス変化―

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Abstract

Although the exact etiology of burning mouth syndrome （BMS） is still unknown, there are three leading hypotheses: the first is that BMS is caused by a disorder of the peripheral nervous system as a neuropathic pain; the second is that BMS is caused by a disorder of the central nervous system associated with stress and anxiety; and the third is that both hypotheses are involved in BMS. In this article, we summarize reports that epigenetics such as DNA methylation and histone modifications in the peripheral and central nervous systems may be involved in the pathogenesis of BMS.

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