Erdheim-Chester Disease Involving the Central Nervous System with Latent Toxoplasmosis
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- Wadayama Tomoya
- Department of Neurology, Osaka University Graduate School of Medicine, Japan
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- Shimizu Mikito
- Department of Neurology, Osaka University Graduate School of Medicine, Japan
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- Kimura Ikko
- Graduate School of Frontier Biosciences, Osaka University, Japan
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- Baba Kousuke
- Department of Neurology, Osaka University Graduate School of Medicine, Japan
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- Beck Goichi
- Department of Neurology, Osaka University Graduate School of Medicine, Japan
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- Nagano Seiichi
- Department of Neurology, Osaka University Graduate School of Medicine, Japan
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- Morita Ryo
- Department of Infectious Diseases, Osaka City General Hospital, Japan
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- Nakagawa Hidenori
- Department of Infectious Diseases, Osaka City General Hospital, Japan
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- Shirano Michinori
- Department of Infectious Diseases, Osaka City General Hospital, Japan
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- Goto Tetsushi
- Department of Infectious Diseases, Osaka City General Hospital, Japan
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- Norose Kazumi
- Department of Infection and Host Defense, Graduate School of Medicine, Chiba University, Japan
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- Hikosaka Kenji
- Department of Infection and Host Defense, Graduate School of Medicine, Chiba University, Japan
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- Murayama Shigeo
- Department of Neurology, Osaka University Graduate School of Medicine, Japan
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- Mochizuki Hideki
- Department of Neurology, Osaka University Graduate School of Medicine, Japan
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Abstract
<p>Erdheim-Chester disease (ECD) is a rare, non-Langerhans cell histiocytosis characterized by the infiltration of foamy histiocytes into multiple organs. We herein report a case of ECD with central nervous system (CNS) involvement in a 63-year-old man who also presented a positive result for Toxoplasma gondii nested polymerase chain reaction testing of cerebrospinal fluid. Since anti-Toxoplasma treatment proved completely ineffective, we presumed latent infection of the CNS with T. gondii. This case suggests the difficulty of distinguishing ECD with CNS involvement from toxoplasmic encephalitis and the possibility of a relationship between the pathogeneses of ECD and infection with T. gondii. </p>
Journal
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- Internal Medicine
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Internal Medicine 61 (17), 2661-2666, 2022-09-01
The Japanese Society of Internal Medicine