State of anxiety may be associated with exocrine pancreatic insufficiency in functional dyspepsia patients with pancreatic enzyme abnormalities
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- Agawa Shuhei
- Division of Gastroenterology, Department of Internal Medicine, Nippon Medical School
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- Futagami Seiji
- Division of Gastroenterology, Department of Internal Medicine, Nippon Medical School
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- Yamawaki Hiroshi
- Division of Gastroenterology, Department of Internal Medicine, Nippon Medical School
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- Gudis Katya
- Division of Gastroenterology, Department of Internal Medicine, Nippon Medical School
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- Higuchi Kazutoshi
- Division of Gastroenterology, Department of Internal Medicine, Nippon Medical School
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- Kaneko Keiko
- Division of Gastroenterology, Department of Internal Medicine, Nippon Medical School
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- Habiro Mayu
- Division of Gastroenterology, Department of Internal Medicine, Nippon Medical School
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- Kodaka Yasuhiro
- Division of Gastroenterology, Department of Internal Medicine, Nippon Medical School
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- Ueki Nobue
- Division of Gastroenterology, Department of Internal Medicine, Nippon Medical School
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- Watanabe Yoshiyuki
- Division of Gastroenterology, St. Marianna University School of Medicine
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- Motoda Norio
- Division of Pathology, Department of Internal Medicine, Nippon Medical School
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- Ohashi Ryuji
- Division of Pathology, Department of Internal Medicine, Nippon Medical School
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- Iwakiri Katsuhiko
- Division of Gastroenterology, Department of Internal Medicine, Nippon Medical School
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<p>We have reported that refractory functional dyspepsia patients with pancreatic enzyme abnormalities (FD-P). We tried to analyze the prevalence of exocrine pancreatic insufficiency (EPI) in FD-P patients to clarify whether the pathophysiology of FD patients including clinical symptoms and quality of life were associated with EPI. We enrolled forty-nine patients presenting with typical symptoms of FD-P patients (n = 20) and asymptomatic patients with pancreatic enzyme abnormalities (AP-P) (n = 29). Five pancreatic enzymes (p-amylase, lipase, elastase-1, trypsin, and PLA2) were measured and STAI-state/-trait and SF-8 were evaluated. Pancreatic exocrine function was analyzed using N-benzoyl-l-tyrosyl-p-aminobenzoic acid (BT-PABA). There were no significant differences in patient background between FD-P and AP-P patients. BT-PABA test scores for FD-P patients (61.67 ± 5.55) were significantly (p = 0.01) lower than in AP-P patients (95.38 ± 2.36). Physical component scale (PCS) in FD-P patients was significantly (p = 0.002) lower than that in AP-P patients. STAI-state was relatively (p = 0.054) associated with BT-PABA test in FD-P and AP-P patients by multiple logistic regression analysis. The prevalence of EPI in FD-P patients was significantly higher than that in AP-P patients and was relatively associated with state of anxiety. Further studies will be needed to clarify how EPI or pancreatic enzyme abnormalities are associated with the pathophysiology of FD-P patients.</p>
収録刊行物
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- Journal of Clinical Biochemistry and Nutrition
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Journal of Clinical Biochemistry and Nutrition 70 (2), 175-181, 2022
一般社団法人 日本酸化ストレス学会
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詳細情報 詳細情報について
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- CRID
- 1390291767463896960
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- NII論文ID
- 130008165950
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- ISSN
- 18805086
- 09120009
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- Crossref
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- KAKEN
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