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- OZONO YOSHIYUKI
- 2nd Department of Internal Medicine of Nagasaki University,
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- HARADA TAKASHI
- 2nd Department of Internal Medicine of Nagasaki University,
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- YAMAGUCHI KOICHI
- 2nd Department of Internal Medicine of Nagasaki University,
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- TAURA KOICHI
- 2nd Department of Internal Medicine of Nagasaki University,
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- HARA KOHEI
- 2nd Department of Internal Medicine of Nagasaki University,
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- TAGUCHI TAKASHI
- 2nd Department of Pathology of Nagasaki University
抄録
Clinical and pathological findings and the effects of therapy were investigated in 90 cases of nephrotic syndrome (NS) in elderly patients aged over 60 years. Membranous nephropathy was the most frequent type of primary NS. Amyloidosis and malignancy were common causes of secondary NS. Damage to the interstitium in the kidney, such as focal mononuclear cell infiltration, fibrosis and thickening of the small arterial wall in membranous cases, was often observed. Stage I and II based on electron-microscopy, were mainly observed in the patients, with membranous nephropathy. Prednisolone and immunosuppressive agent were most effective in these patients with membranous nephropathy. Prednisolone alone was the most effective on minimal change NS in the elderly. In the course of therapy, side effects such as pneumonia, sepsis due to fungus infections, such as aspergillus and candida, and infection, such as cytomegalovirus and herpes zoster, were more frequently observed, especially in the cases of MPGN, DPGN with moderate to severe mesangial proliferation, with a decline in renal function (Ccr<50 L/day) and secondary NS. In secondary NS, the prognosis of amyloidosis was very poor and the findings pointed to a relationship between malignancy and nephrotic syndrome.
収録刊行物
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- 日本腎臓学会誌
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日本腎臓学会誌 36 (1), 44-50, 1994
社団法人 日本腎臓学会