Preconception folic acid supplementation use and the occurrence of neural tube defects in Japan: A nationwide birth cohort study of the Japan Environment and Children's Study

• Hidekazu Nishigori

  Department of Obstetrics and Gynecology Tohoku University Graduate School of Medicine Sendai Miyagi Japan

• Taku Obara

  Environment and Genome Research Center Tohoku University Graduate School of Medicine Sendai Miyagi Japan

• Toshie Nishigori

  Department of Obstetrics and Gynecology Tohoku University Graduate School of Medicine Sendai Miyagi Japan

• Mami Ishikuro

  Tohoku Medical Megabank Organization Tohoku University Sendai Miyagi Japan

• Kasumi Sakurai

  Environment and Genome Research Center Tohoku University Graduate School of Medicine Sendai Miyagi Japan

• Tetsuro Hoshiai

  Department of Obstetrics and Gynecology Tohoku University Graduate School of Medicine Sendai Miyagi Japan

• Masatoshi Saito

  Department of Obstetrics and Gynecology Tohoku University Graduate School of Medicine Sendai Miyagi Japan

• Ikuma Fujiwara

  Environment and Genome Research Center Tohoku University Graduate School of Medicine Sendai Miyagi Japan

• Takahiro Arima

  Environment and Genome Research Center Tohoku University Graduate School of Medicine Sendai Miyagi Japan

• Kunihiko Nakai

  Environment and Genome Research Center Tohoku University Graduate School of Medicine Sendai Miyagi Japan

• Shinichi Kuriyama

  Environment and Genome Research Center Tohoku University Graduate School of Medicine Sendai Miyagi Japan

• Nariyasu Mano

  Department of Pharmaceutical Sciences Tohoku University Hospital Sendai Miyagi Japan

• Hirohito Metoki

  Division of Public Health, Hygiene and Epidemiology, Faculty of Medicine Tohoku Medical and Pharmaceutical University Sendai Japan

• Nobuo Yaegashi

  Department of Obstetrics and Gynecology Tohoku University Graduate School of Medicine Sendai Miyagi Japan

Abstract

We evaluated the relationship between preconception folic acid supplementation and the occurrence of neural tube defects (NTDs) in offspring, using data from the Japan Environment and Children's Study (a nationwide prospective birth cohort study) database. Of 92 269 participants with single pregnancies, 74 cases (offspring or fetuses) had NTDs, including 32 cases of spina bifida, 24 cases of anencephaly, and 19 cases of encephalocele. A total of 7634 participants (8.27%) used preconception folic acid supplementation, and of these, 621 (0.67%) also took in dietary folic acid at ≥480 μg/day. Multivariate logistic regression analyses demonstrated no association between preconception folic acid supplementation and NTDs in offspring or fetuses (odds ratio [OR] 0.622; 95% confidence interval [CI]: 0.226‐1.713). Moreover, the participants who combined preconception folic acid supplement use with dietary folic acid intake ≥480 μg/day demonstrated no incidence of NTDs in offspring or fetuses. Our analysis is limited by the absence of the data on the daily amount of supplementary folic acid intake, requiring careful attention to the interpretation. Additional surveys are required in Japan to resolve those limitations for further comprehensive assessment.

Journal

• Congenital Anomalies

  Congenital Anomalies 59 (4), 110-117, 2018-07-12

  Wiley

Keywords

• Developmental Biology
• Embryology
• General Medicine
• Pediatrics, Perinatology and Child Health

Details

• CRID: 1360847871300985216
• NII Article ID: 210000012723
• DOI: 10.1111/cga.12293
• ISSN: 17414520
• ISSN: 09143505
• Web Site: https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fcga.12293
• Web Site: https://onlinelibrary.wiley.com/doi/pdf/10.1111/cga.12293
• Web Site: https://onlinelibrary.wiley.com/doi/full-xml/10.1111/cga.12293
• Data Source:
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  • CiNii Articles