Design and experimental demonstration of low-power CMOS magnetic cell manipulation platform using charge recycling technique

Abstract

<jats:title>Abstract</jats:title> <jats:p>We present the world’s first charge-recycling-based low-power technique of complementary metal–oxide–semiconductor (CMOS) magnetic cell manipulation. CMOS magnetic cell manipulation associated with magnetic beads is a promissing tool for on-chip biomedical-analysis applications such as drug screening because CMOS can integrate control electronics and electro-chemical sensors. However, the conventional CMOS cell manipulation requires considerable power consumption. In this work, by concatenating multiple unit circuits and recycling electric charge among them, power consumption is reduced by a factor of the number of the concatenated unit circuits (1/<jats:italic>N</jats:italic>). For verifying the effectiveness, test chip was fabricated in a 0.6-µm CMOS. The chip successfully manipulates magnetic microbeads with achieving 49% power reduction (from 51 to 26.2 mW). Even considering the additional serial resistance of the concatenated inductors, nearly theoretical power reduction effect can be confirmed.</jats:p>

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