Parenchymal calcification is associated with the neurological prognosis in patients with congenital rubella syndrome

• Takahiro Namiki

  Nihon University School of Medicine Tokyo Japan

• Chika Takano

  Division of Microbiology, Department of Pathology and Microbiology Nihon University School of Medicine Tokyo Japan

• Ryoji Aoki

  Department of Pediatrics and Child Health Nihon University School of Medicine Tokyo Japan

• Quang Duy Trinh

  Division of Microbiology, Department of Pathology and Microbiology Nihon University School of Medicine Tokyo Japan

• Ichiro Morioka

  Department of Pediatrics and Child Health Nihon University School of Medicine Tokyo Japan

• Satoshi Hayakawa

  Division of Microbiology, Department of Pathology and Microbiology Nihon University School of Medicine Tokyo Japan

Abstract

Congenital rubella syndrome (CRS) results from maternal rubella virus infection in early pregnancy. Abnormal neuroimaging findings have been analyzed in a small number of CRS patients in the past; however, their clinical significance has been poorly addressed. Therefore, we have investigated the neuroimaging findings of 31 patients with CRS from previous studies. The most common finding was parenchymal calcification, which was observed in 18 of 31 patients (58.1%). A multivariable logistic regression model showed that it was associated with psychomotor or mental retardation (p = 0.018), suggesting that parenchymal calcification in CRS could be a prognostic factor.

Journal

• Congenital Anomalies

  Congenital Anomalies 62 (1), 38-41, 2021-08-23

  Wiley

Details

• CRID: 1360289088621984896
• NII Article ID: 210000159243
• DOI: 10.1111/cga.12442
• ISSN: 17414520
• ISSN: 09143505
• Web Site: https://onlinelibrary.wiley.com/doi/pdf/10.1111/cga.12442
• Web Site: https://onlinelibrary.wiley.com/doi/full-xml/10.1111/cga.12442
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