Can myocardial susceptibility quantification be an imaging biomarker for cardiac amyloidosis?

• Hidetaka Hayashi

• Seitaro Oda

• Masafumi Kidoh

• Takeshi Nakaura

• Kosuke Morita

• Yasunori Nagayama

• Tetsuya Yoneda

• Seiji Takashio

• Yohei Misumi

• Mitsuharu Ueda

• Kenichi Tsujita

• Toshinori Hirai

抄録

This study aimed to evaluate whether quantification of myocardial susceptibility by cardiac magnetic resonance imaging (CMR) can be an imaging biomarker for cardiac amyloidosis (CA). Twenty-six patients with CA underwent CMR, including magnetic phase imaging with a 3.0-T magnetic resonance imaging scanner. Myocardial susceptibility was quantified as a phase shift slope value by magnetic phase analysis. Those values from patients with CA were compared with corresponding values from 18 controls and 15 healthy volunteers. A univariate logistic regression analysis was conducted to identify significant parameters related to CA. The phase shift slope, a quantitative parameter of myocardial susceptibility, was significantly lower in the CA group compared with the control group and compared with healthy volunteers ( p  < 0.01). From a total of 17 tested variables, 6 were considered to be significant predictors of CA ( p  ≤ 0.05) during the univariate analysis. The phase shift slope yielded the best AUC of 0.89 (95% CI = 0.79–0.98) for the prediction of CA ( p  < 0.01). The phase shift slope was significantly correlated with the end-diastolic thickness of the interventricular septum ( r  =  − 0.39, p  < 0.01) and posterior wall of the left ventricle ( r  =  − 0.35, p  = 0.02). Myocardial susceptibility analysis by CMR helps in the diagnosis of patients with CA and can be a new quantitative imaging biomarker for CA.

収録刊行物

• Japanese Journal of Radiology

  Japanese Journal of Radiology 40 (5), 500-507, 2021-11-29

  Springer Science and Business Media LLC

キーワード

• Radiology, Nuclear Medicine and imaging

詳細情報

• CRID: 1360008786275227520
• NII論文ID: 210000160917
• DOI: 10.1007/s11604-021-01228-z
• ISSN: 1867108X
• ISSN: 18671071
• Web Site: https://link.springer.com/content/pdf/10.1007/s11604-021-01228-z.pdf
• Web Site: https://link.springer.com/article/10.1007/s11604-021-01228-z/fulltext.html
• Web Site: https://search.jamas.or.jp/link/ui/2023157680
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