Magnetic resonance cisternography imaging findings related to the leakage of Gadolinium into the subarachnoid space

• Rei Nakamichi

• Toshiaki Taoka

• Hisashi Kawai

• Tadao Yoshida

• Michihiko Sone

• Shinji Naganawa

Abstract

To identify magnetic resonance cisternography (MRC) imaging findings related to Gadolinium-based contrast agent (GBCA) leakage into the subarachnoid space. The number of voxels of GBCA leakage (V-leak) on 3D-real inversion recovery images was measured in 56 patients scanned 4 h post-intravenous GBCA injection. Bridging veins (BVs) were identified on MRC. The numbers of BVs with surrounding cystic structures (BV-cyst), with arachnoid granulations protruding into the superior sagittal sinus (BV-AG-SSS) and the skull (BV-AG-skull), and including any of these factors (BV-incl) were recorded. Correlations between these variables and V-leak were examined based on the Spearman’s rank correlation coefficient. Receiver-operating characteristic (ROC) curves were generated to investigate the predictive performance of GBCA leakage. V-leak and the number of BV-incl were strongly correlated ( r  = 0.609, p  < 0.0001). The numbers of BV-cyst and BV-AG-skull had weaker correlations with V-leak ( r  = 0.364, p  = 0.006; r  = 0.311, p  = 0.020, respectively). The number of BV-AG-SSS was not correlated with V-leak. The ROC curve for contrast leakage exceeding 1000 voxels and the number of BV-incl had moderate accuracy, with an area under the curve of 0.871. The number of BV-incl may be a predictor of GBCA leakage and a biomarker for waste drainage function without using GBCA.

Journal

• Japanese Journal of Radiology

  Japanese Journal of Radiology 39 (10), 927-937, 2021-05-29

  Springer Science and Business Media LLC

Keywords

• Radiology, Nuclear Medicine and imaging

Details

• CRID: 1361415748543902208
• NII Article ID: 210000178112
• DOI: 10.1007/s11604-021-01137-1
• ISSN: 1867108X
• ISSN: 18671071
• Web Site: https://link.springer.com/content/pdf/10.1007/s11604-021-01137-1.pdf
• Web Site: https://link.springer.com/article/10.1007/s11604-021-01137-1/fulltext.html
• Web Site: https://search.jamas.or.jp/link/ui/2022185865
• Data Source:
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  • CiNii Articles
  • KAKEN