Genetic epidemiological studies of early‐onset deafness in the U.S. school‐age population

DOI Web Site Web Site 被引用文献11件

抄録

<jats:title>Abstract</jats:title><jats:p>Profound, early‐onset deafness is present in 4–11 per 10,000 children, and is attributable to genetic causes in at least 50% of cases.</jats:p><jats:p>Family history questionnaires were sent to 26,152 families of children with profound, early‐onset deafness not known to be related to an environmental cause. The probands were ascertained through the 1988–89 Gallaudet University Annual Survey of Hearing Impaired Children and Youth. The analysis is based on the responses that were received from 8,756 families.</jats:p><jats:p>Classical segregation analysis was used to analyze the family data, and to estimate the proportions of sporadic, recessive and dominant causes of deafness in the families. These data were consistent with 37.2% of the cases due to sporadic causes, and 62.8% due to genetic causes (47.1% recessive, and 15.7% dominant). An earlier study using the 1969–70 Annual Survey found 49.3% sporadic cases and 50.6% genetic, demonstrating that the proportion of sporadic cases of early‐onset deafness has significantly decreased since 1970. © 1993 Wiley‐Liss, Inc.</jats:p>

収録刊行物

被引用文献 (11)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ