Bone‐bonding ability of P₂O₅‐Free CaO · SiO₂ glasses

• Kouichiro Ohura

• Takashi Nakamura

• Takao Yamamuro

• Tadashi Kokubo

• Yukihiro Ebisawa

• Yoshihiko Kotoura

• Masanori Oka

抄録

An apatite‐ and wollastonite‐containing glass‐ceramic (A · W‐GC) has been reported to form a tight bond with living bone through an apatite layer formed on its surface. This layer is considered to be formed by dissolution of Ca 2+ and HSiO 3 − ions from the glass‐ceramic into the surrounding body fluids. In order to confirm this proposed mechanism for the surface reaction of A · W‐GC, three kinds of glass in the systems CaOSiO 2 , CaOSiO 2 CaF 2 , and CaOSiO 2 P 2 O 5 were implanted into the tibiae of rabbits for 3 or 8 weeks. Contact microradiography and SEM‐EPMA showed that all three kinds of glass formed a Ca, P‐rich layer in combination with a Si‐rich layer on their surfaces within 3 weeks and formed a direct bond with bone via these layers. The detaching test, performed 8 weeks after implantation, showed that the loads required to detach the implants from the bone were almost equal for the phosphorus‐free and the phosphorus‐containing glasses. It was concluded that even P 2 O 5 ‐free CaO · SiO 2 glass formed a Ca,P‐rich layer on its surface and bonded tightly with living bone. If glasses and glass‐ceramics release at least Ca 2+ and HSiO 3 − ions, this would be sufficient for them to form the Ca,P‐rich layer on their surfaces in vivo , enabling them to bond directly with bone.

収録刊行物

• Journal of Biomedical Materials Research

  Journal of Biomedical Materials Research 25 (3), 357-365, 1991-03

  Wiley

キーワード

• Biomedical Engineering
• Biomaterials

詳細情報

• CRID: 1360574094698238720
• NII論文ID: 30002071684
• DOI: 10.1002/jbm.820250307
• ISSN: 10974636
• ISSN: 00219304
• Web Site: https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fjbm.820250307
• Web Site: https://onlinelibrary.wiley.com/doi/pdf/10.1002/jbm.820250307
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