Perineuritis in mononeuritis multiplex with cryoglobulinemia

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<jats:title>Abstract</jats:title><jats:p>A case with mononeuritis multiplex associated with mixed cryoglobulinemia and mild persistent hepatitis is reported. Sural nerve biopsy specimens revealed thickening of the perineurium and vascular alterations with inflammatory cells infiltrating into the perineurium as well as the epineurium and endoneurium, thus having the features of perineuritis. Most myelinated and unmyelinated nerve fibers were lost. A therapeutic trial of corticosteroids decreased the serum titer of cryoglobulin without any improvement of clinical features.</jats:p>

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