Glaucomatous Optic Neuropathy: When Glia Misbehave

• Arthur H. Neufeld

  Department of Ophthalmology and Visual Sciences Washington University School of Medicine, St. Louis, Missouri

• Bin Liu

抄録

The loss of vision in the human eye disease, glaucoma, is due to degeneration of the axons of the retinal ganglion cells. In glaucoma, reactive astrocytes in the optic nerve head contain inducible nitric oxide synthase, which apparently produces excessive nitric oxide that damages the axons. The astrocytes respond to the elevated intraocular pressure that is characteristic of the disease. An important signal transduction pathway for the induction of nitric oxide synthase in response to pressure is the epidermal growth factor receptor tyrosine kinase. Pharmacological inhibition of the activity or the induction of inducible nitric oxide synthase may provide neuroprotection for the treatment of glaucoma.

収録刊行物

• The Neuroscientist

  The Neuroscientist 9 (6), 485-495, 2003-12

  SAGE Publications

キーワード

• Neurology (clinical)
• General Neuroscience

詳細情報

• CRID: 1363951794568948608
• NII論文ID: 30006493547
• DOI: 10.1177/1073858403253460
• ISSN: 10894098
• ISSN: 10738584
• Web Site: http://journals.sagepub.com/doi/pdf/10.1177/1073858403253460
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