Evaluation of Myocardial Glucose Metabolism Before and After Recovery of Myocardial Function in Patients with Tachycardia‐Induced Cardiomyopathy

• KATSUMI MATSUMOTO

• NOBUKAZU TAKAHASHI

• TOSHIYUKI ISHIKAWA

• SHINICHI SUMITA

• KOHEI MATSUSHITA

• NORIKO INOUE

• TSUKASA KOBAYASHI

• KAZUAKI UCHINO

• KAZUO KIMURA

• TOMIO INOUE

• SATOSHI UMEMURA

抄録

Background: We assessed left ventricular (LV) function and myocardial glucose metabolism by fluoro‐18‐deoxyglucose ( 18 F‐FDG) positron emission tomography (PET) in patients with tachycardia‐induced cardiomyopathy (TC). Methods: The subjects were 42 patients with heart disease, consisting of 7 patients with TC (61.4 ± 19.0 years, LVEF 34.1%± 10.6%) and 35 with ischemic heart disease (IHD) (63.1 ± 10.8 years, LVEF 49.9%± 13.5%). Five volunteers with normal ECG were the control group. All of the patients underwent 18 F‐FDG PET and echocardiography, and all of the patients with TC underwent 18 F‐FDG PET and echocardiography before and 6 months after antitachycardia therapy. Six patients underwent radiofrequency catheter ablation (RFCA) and 1 patient was medically treated with antitachycardia therapy. Myocardial glucose metabolism was assessed semiquantitatively by using the % dose uptake of 60 kg of BW (% dose uptake). Results: Mean % dose uptake of the control group was 5.52 ± 0.54%. After antitachycardia therapy, LVEF significantly improved (34.1 ± 10.6% vs 54.3 ± 13.6%, P < 0.01), and % dose uptake also significantly improved (1.26 ± 0.55% vs 1.49 ± 0.62%, P < 0.05). Patients with IHD showed higher % dose uptake than those with TC before antitachycardia therapy (3.18 ± 1.36 vs 1.26 ± 0.55%, P < 0.01), controls showed higher value of % dose uptake than TC before antitachycardia therapy (5.52 ± 0.54% vs 1.26 ± 0.55%, P < 0.01). Conclusion: Semiquantitative analysis of 18 F‐FDG PET showed that antitachycardia therapy improved myocardial glucose metabolism in patients with TC.

収録刊行物

• Pacing and Clinical Electrophysiology

  Pacing and Clinical Electrophysiology 29 (2), 175-180, 2006-02

  Wiley

キーワード

• Cardiology and Cardiovascular Medicine
• General Medicine

詳細情報

• CRID: 1360574094736057984
• NII論文ID: 30006583798
• DOI: 10.1111/j.1540-8159.2006.00313.x
• ISSN: 15408159
• ISSN: 01478389
• Web Site: https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1540-8159.2006.00313.x
• Web Site: https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1540-8159.2006.00313.x
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  • CiNii Articles