Hydrogen Peroxide: A Key Messenger That Modulates Protein Phosphorylation Through Cysteine Oxidation

DOI Web Site 被引用文献9件
  • Sue Goo Rhee
    S. G. Rhee, S.-R. Lee, and J. Kwon are at the Laboratory of Cell Signaling, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.(S.G.R.)
  • Yun Soo Bae
    S. G. Rhee, S.-R. Lee, and J. Kwon are at the Laboratory of Cell Signaling, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.(S.G.R.)
  • Seung-Rock Lee
    S. G. Rhee, S.-R. Lee, and J. Kwon are at the Laboratory of Cell Signaling, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.(S.G.R.)
  • Jaeyul Kwon
    S. G. Rhee, S.-R. Lee, and J. Kwon are at the Laboratory of Cell Signaling, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.(S.G.R.)

抄録

<jats:p> Ligand-receptor interactions can generate the production of hydrogen peroxide (H <jats:sub>2</jats:sub> O <jats:sub>2</jats:sub> ) in cells, the implications of which are becoming appreciated. Fluctuations in H <jats:sub>2</jats:sub> O <jats:sub>2</jats:sub> levels can affect the intracellular activity of key signaling components including protein kinases and protein phosphatases. Rhee <jats:italic>et al</jats:italic> . discuss recent findings on the role of H <jats:sub>2</jats:sub> O <jats:sub>2</jats:sub> in signal transduction. Specifically, H <jats:sub>2</jats:sub> O <jats:sub>2</jats:sub> appears to oxidize active site cysteines in phosphatases, thereby inactivating them. H <jats:sub>2</jats:sub> O <jats:sub>2</jats:sub> also can activate protein kinases; however, although the mechanism of activation for some kinases appears to be similar to that of phosphatase inactivation (cysteine oxidation), it is unclear how H <jats:sub>2</jats:sub> O <jats:sub>2</jats:sub> promotes increased activation of other kinases. Thus, the higher levels of intracellular phosphoproteins observed in cells most likely occur because of the concomitant inhibition of protein phosphatases and activation of protein kinases. </jats:p>

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  • Science's STKE

    Science's STKE 2000 (53), pe1-, 2000-10-10

    American Association for the Advancement of Science (AAAS)

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