Variability of the ¹³C‐Acetate Breath Test for Gastric Emptying of Liquids in Healthy Children

• B. Hauser

  Departments of Paediatrics Vrije Universiteit Brussels Brussels Belgium

• J. De Schepper

  Departments of Paediatrics Vrije Universiteit Brussels Brussels Belgium

• V. Caveliers

  Departments of Nuclear Medicine Academisch Ziekenhuis Vrije Universiteit Brussels Brussels Belgium

• S. Salvatore

  Clinica Pediatrica Ospedale F. Del Ponte Universita dell Insubria Varese Italy

• A. Salvatoni

  Clinica Pediatrica Ospedale F. Del Ponte Universita dell Insubria Varese Italy

• Y. Vandenplas

  Departments of Paediatrics Vrije Universiteit Brussels Brussels Belgium

抄録

Scintigraphy is considered as the “gold standard” for measuring gastric emptying (GE). The 13 C‐acetate breath test ( 13 C‐ABT) offers an attractive alternative to measure GE of liquids as it is nonradioactive. The aim of this study was to assess the variability of the 13 C‐ABT for GE of liquids in healthy children using nondispersive infrared spectrometry (NDIRS). The 13 C‐ABT was repeated at least 2 times in 21 healthy children (6 girls and 15 boys), aged between 6.2 and 16.4 years, 2 to 7 days apart. After an overnight fast, a standardized milk drink, labeled with 50 or 100 mg 13 C‐acetate according to weight, was administered. Breath samples were taken before feeding, at 5‐minute intervals for the first 40 minutes and at 10‐minute intervals for the following 140 minutes after feeding. Breath samples were analyzed using NDIRS, and 13 C recovery was used to calculate values for gastric half‐emptying time ( t 1/2 ), time of peak 13 C exhalation, or gastric lag phase ( t lag ) and gastric emptying coefficient (GEC). Intraindividual variabilities of the parameters t 1/2 , t lag , and GEC were expressed as coefficient of intrasubject variation (CV). The median CV of t 1/2 was 8.3% (CV range, 1.6%‐16.2%; t 1/2 interindividual range, 65‐112 minutes; and t 1/2 intraindividual range, 4‐33 minutes). The median CV of t lag was 16.6% (CV range, 2.0%‐26.6%; t lag interindividual range, 31‐76 minutes; and t lag intraindividual range, 1‐35 minutes). The median CV of GEC was 4.3% (CV range, 0.8%‐15.7%; GEC interindividual range, 3.81‐4.89; GEC intraindividual range, 0.08‐1.31). The CVs of t 1/2 , t lag , and GEC were independent of age, sex, weight, height, and measured values of t 1/2 , t lag , and GEC. The 13 C‐ABT using NDIRS is an easy, noninvasive, and nonradioactive procedure with a large intraindividual variation for measuring GE of liquids in healthy children, but comparable to the variation reported with other techniques.

収録刊行物

• Journal of Pediatric Gastroenterology and Nutrition

  Journal of Pediatric Gastroenterology and Nutrition 42 (4), 392-397, 2006-04

  Wiley

キーワード

• Gastroenterology
• Pediatrics, Perinatology and Child Health

詳細情報

• CRID: 1360292621243002240
• NII論文ID: 30007566474
• DOI: 10.1097/01.mpg.0000215306.40546.17
• ISSN: 15364801
• ISSN: 02772116
• Web Site: https://onlinelibrary.wiley.com/doi/pdf/10.1097/01.mpg.0000215306.40546.17
• データソース種別:
  • Crossref
  • CiNii Articles