Differentiation of clinically benign and malignant breast lesions using diffusion‐weighted imaging

• Yong Guo

• You‐Quan Cai

• Zu‐Long Cai

• Yuan‐Gui Gao

• Ning‐Yu An

• Lin Ma

• Srikanth Mahankali

• Jia‐Hong Gao

Abstract

To evaluate the value of diffusion‐weighted imaging (DWI) in distinguishing between benign and malignant breast lesions. Fifty‐two female subjects (mean age = 58 years, age range = 25–75 years) with histopathologically proven breast lesions underwent DWI of the breasts with a single‐shot echo‐planar imaging (EPI) sequence using large b values. The computed mean apparent diffusion coefficients (ADCs) of the breast lesions and cell density were then correlated. The ADCs varied substantially between benign breast lesions ((1.57 ± 0.23) × 10 −3 mm 2 /second) and malignant breast lesions ((0.97 ± 0.20) × 10 −3 mm 2 /second). In addition, the mean ADCs of the breast lesions correlated well with tumor cellularity (P < 0.01, r = −0.542). The ADC would be an effective parameter in distinguishing between malignant and benign breast lesions. Further, tumor cellularity has a significant influence on the ADCs obtained in both benign and malignant breast tumors. J. Magn. Reson. Imaging 2002;16:172–178. © 2002 Wiley‐Liss, Inc.

Journal

• Journal of Magnetic Resonance Imaging

  Journal of Magnetic Resonance Imaging 16 (2), 172-178, 2002-07-23

  Wiley

Keywords

• Radiology, Nuclear Medicine and imaging

Details

• CRID: 1362825893380396544
• NII Article ID: 30008695811
• DOI: 10.1002/jmri.10140
• ISSN: 15222586
• ISSN: 10531807
• Web Site: https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fjmri.10140
• Web Site: https://onlinelibrary.wiley.com/doi/pdf/10.1002/jmri.10140
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