Elevated serum levels of tumor necrosis factor‐α in Guillain‐Barré syndrome

DOI Web Site Web Site 被引用文献2件

抄録

<jats:title>Abstract</jats:title><jats:p>Activated T lymphocytes and macrophages play a putative role in the pathogenesis of Guillian‐Barré syndrome. Both cell types secrete tumor necrosis factor‐α, a cytokine that has well‐recognized toxi effects on myelin, Schwann cells, and endothelial cells. We determined serum and cerebrospinal fluid concentrations of tumor necrosis factor α in 26 patients with Guillain‐Barré syndrome, 27 patients with other polyneuropathies, 30 patients with neurological diseases of the central nervous system, and 14 helthy control subjects. Markedly increased serum levels were detected in 14 patients(54%) with Guillian‐Barré syndrome and to a significantly lesser extent, in patients with other polyneuropathies (26%) and in neurological control subjects(23%). Tumor necrosis factor‐α was not detected in the cerebrospinal fluid of patients with Guillain‐Barré syndrome or other polyneuropathies. Increased serum concentrations in patients with Guillain‐Barré syndrome or other polyneuropathies. Increased serum concentrations in patients with Guillain‐Barré syndrome correlated directly with disease severity and these concentrations returned to normal in parallel with clinical recovery. These findings emphasize the complexity of the immune response in patients with Guillain‐Barré syndrome and suggest that tumor necrosis factor‐αL may be important in the pathogenesis of peripheral demylination in this disorder.</jats:p>

収録刊行物

被引用文献 (2)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ