A Multicenter Validation of Regional Cerebral Blood Flow Quantitation Using [<sup>123</sup>I]Iodoamphetamine and Single Photon Emission Computed Tomography

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  • Hidehiro Iida
  • Tooru Akutsu
    Department of Radiology, Yamagata University School of Medicine, Yamagata
  • Keigo Endo
    Department of Nuclear Medicine, Gunma University School of Medicine, Gunma
  • Hiroshi Fukuda
    Department of Nuclear Medicine and Radiology, Institute of Development, Aging and Cancer, Miyage University, Tohoku
  • Takeshi Inoue
    Department of Radiology, Ehime University School of Medicine, Ehime
  • Hiroshi Ito
    Department of Nuclear Medicine and Radiology, Institute of Development, Aging and Cancer, Miyage University, Tohoku
  • Sukehiko Koga
    Department of Radiology, Fujita Health University School of Medicine, Aichi
  • Akio Komatani
    Department of Radiology, Yamagata University School of Medicine, Yamagata
  • Yasuo Kuwabara
    Department of Radiology, Faculty of Medicine, Kyushu University, Fukuoka, Japan
  • Toshimitsu Momose
  • Sadahiko Nishizawa
    Department of Nuclear Medicine, Kyoto University, School of Medicine, Kyoto
  • Ikuo Odano
    Department of Radiology, Niigata University School of Medicine, Niigata
  • Masaki Ohkubo
    Department of Radiology, Niigata University School of Medicine, Niigata
  • Yasuhito Sasaki
    Department of Radiology, Faculty of Medicine, University of Tokyo, Tokyo
  • Hideki Suzuki
    Department of Nuclear Medicine, Gunma University School of Medicine, Gunma
  • Shuuji Tanada
    Department of Radiology, Ehime University School of Medicine, Ehime
  • Hiroshi Toyama
    Department of Radiology, Fujita Health University School of Medicine, Aichi
  • Yoshiharu Yonekura
    Department of Nuclear Medicine, Kyoto University, School of Medicine, Kyoto
  • Tsuyoshi Yoshida
    Department of Radiology, Faculty of Medicine, Kyushu University, Fukuoka, Japan
  • Kazuo Uemura

抄録

<jats:p> Recently, two methods have been proposed for regional cerebral blood flow (rCBF) quantitation using [<jats:sup>123</jats:sup>I]iodoamphetamine (IMP) and single-photon emission computed tomography (SPECT). The table look-up (TLU) method has been shown to provide both rCBF and volume of distribution, V<jats:sub>d</jats:sub>, images from two SPECT scans, while a single-scan autoradiographic (ARG) technique provided rCBF using a fixed and assumed V<jats:sub>d</jats:sub>. In both methods, a single blood sample was referred to calibrate the previously determined standard input function The present multicenter project was designed to evaluate the accuracy of both methods for use as clinical investigative tools. Ten independent institutions performed [<jats:sup>123</jats:sup>I]IMP-SPECT studies according to both methods in 76 subjects (10 normal volunteers, 32 patients with cerebrovascular disease, and 34 patients with other diseases). Calculated rCBF values were compared with those obtained by the following reference methods available in the participating institutions; [<jats:sup>15</jats:sup>O] H<jats:sub>2</jats:sub>O positron emission tomography (PET) (five institutions), [<jats:sup>133</jats:sup>Xe]SPECT (four institutions), and the [<jats:sup>123</jats:sup>I]IMP microsphere method (three institutions). Both ARG and TLU methods provided rCBF values that were significantly correlated with those measured by the [<jats:sup>15</jats:sup>O] H<jats:sub>2</jats:sub>O PET technique ( p < 0.001 for all subjects; overall regression equation, y = 15.14 + 0.54×) and those measured by the [<jats:sup>123</jats:sup>I]IMP-microsphere method ( p < 0.001 for all subjects; y = 2.0 + 0.80×). Significant correlation ( p < 0.05) was observed in 18 of 24 subjects studied with the [<jats:sup>133</jats:sup>Xe] SPECT reference technique (overall regression equation, y = 15.0 + 0.55×). Mean cortical gray matter rCBF in a group of normal subject was 43.9 ± 3.3 and 43.4 ± 2.0 ml/min/100 g for the ARG and TLU methods, respectively. Regional V<jats:sub>d</jats:sub> of [<jats:sup>123</jats:sup>I]IMP estimated by the TLU method was 45 ml/ml ± 20% in the normal cortical region. Close agreement between ARG and TLU rCBF values was observed (y = −3.21 + 1.07×, r = 0.97), confirming the validity of assuming a fixed V<jats:sub>d</jats:sub> in the ARG method. Results of this study demonstrate that both the ARG and TLU methods accurately and reliably estimate rCBF in a variety of clinical settings. </jats:p>

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