Olfactory Neuroblastoma: Past, Present, and Future?

• Valerie J. Lund

• David Howard

• William Wei

• Margaret Spittle

抄録

Objective To consider the long‐term survival and outcomes in patients with olfactory neuroblastoma undergoing craniofacial resection. Study Design A single‐center prospective cohort study. Methods All patients with olfactory neuroblastoma treated in a 23‐year period with craniofacial resection (with or without radiotherapy) were analyzed; a multivariate analysis was included. Results Forty‐two patients aged 12 to 70 years were assessed, 83% of whom had received no preceding treatment. Craniofacial resection was used in all cases, combined with radiotherapy in 24 patients (57%). Duration of follow‐up ranged from 2 to 206 months (mean follow‐up period, 57 mo). The disease‐free actuarial survival and overall survival were 77% and 61% at 5 years and 53% and 42% at 10 years, respectively. A Cox regression analysis identified intracranial extension and orbital involvement as independent factors affecting outcome. Conclusion Craniofacial resection combined with radiotherapy offers the gold standard of care against which other approaches such as endoscopic resection must be judged.

収録刊行物

• The Laryngoscope

  The Laryngoscope 113 (3), 502-507, 2003-03

  Wiley

キーワード

• Otorhinolaryngology

詳細情報

• CRID: 1364233268614003072
• NII論文ID: 30009419596
• NII書誌ID: AA00714953
• DOI: 10.1097/00005537-200303000-00020
• ISSN: 15314995
• ISSN: 0023852X
• Web Site: https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1097%2F00005537-200303000-00020
• Web Site: https://onlinelibrary.wiley.com/doi/pdf/10.1097/00005537-200303000-00020
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  • CiNii Articles