Effectiveness of Indomethacin as an Antitumor Agent in Colon 26-Bearing Conventional and Nude Mice, and Telomerase Activity in the Tumors.
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- OGINO Mitsuharu
- Department of Obstetrics & Gynecology, The Clinical Research Center, Teikyo University School of Medicine, Ichihara Hospital The Clinical Research Center, Teikyo University School of Medicine, Ichihara Hospital
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- HISATOMI Hisashi
- Center for Molecular Biology and Cytogenetics, SRL, Inc.
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- HANAZONO Makoto
- The Clinical Research Center, Teikyo University School of Medicine, Ichihara Hospital
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The antitumor effect of indomethacin on Colon 26 tumor was investigated in conventional (CDF1) and nude mice (BALB/c nu/nu), and the telomerase activity in the tumor tissues treated with indomethacin was monitored. Growth of Colon 26 tumor was significantly suppressed with indomethacin treatment compared to the controls both in conventional and nude mice. And telomerase activity in the tumor tissues noticeably declined in contrast to normal somatic tissues (testis, liver and colon), which were not affected by indomethacin treatment. We also showed that indomethacin can suppress tumor growth in association with a preferential decrease in telomerase activity in tumor tissues both in conventional and nude mice to the same extent. This study suggests a method for investigating the mechanism of tumor suppression by indomethacin, and suggests that indomethacin might be useful as a novel agent for human cancer therapy.<br>
収録刊行物
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- Experimental Animals
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Experimental Animals 48 (1), 15-21, 1999
公益社団法人 日本実験動物学会
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詳細情報 詳細情報について
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- CRID
- 1390001205042921088
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- NII論文ID
- 10007347464
- 30010196890
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- NII書誌ID
- AA11032321
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- ISSN
- 18817122
- 00075124
- 13411357
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- NDL書誌ID
- 4635996
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- PubMed
- 10067201
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可