Correlation of Primate Caudate Neural Activity and Saccade Parameters in Reward-Oriented Behavior

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  • Hideaki Itoh
    Department of Mathematical Engineering and Information Physics, The University of Tokyo, Tokyo 113-8656;
  • Hiroyuki Nakahara
    Laboratory for Mathematical Neuroscience, RIKEN Brain Science Institute, Saitama 351-0198;
  • Okihide Hikosaka
    Department of Physiology, Juntendo University, School of Medicine, Tokyo 113-8421; and
  • Reiko Kawagoe
    Department of Physiology, Juntendo University, School of Medicine, Tokyo 113-8421; and
  • Yoriko Takikawa
    Department of Physiology, Juntendo University, School of Medicine, Tokyo 113-8421; and
  • Kazuyuki Aihara
    Department of Mathematical Engineering and Information Physics, The University of Tokyo, Tokyo 113-8656;

Abstract

<jats:p> Changes in the reward context are associated with changes in neuronal activity in the basal ganglia as well as changes in motor outputs. A typical example is found in the caudate (CD) projection neurons and saccade parameters. It raised the possibility that the changes in CD neuronal activity contribute to the changes in saccade parameters. To examine this possibility, we calculated the correlation coefficients (CORs) of the firing rates of each neuron with saccade parameters (peak saccade velocity and latency) on a trial-by-trial basis. We then calculated the mean CORs separately for two CD populations: reward-enhanced type neurons (RENs) that showed enhanced activity and reward-depressed type neurons (RDNs) that showed depressed activity when reward was expected. The activity of RENs was positively correlated with the saccadic peak velocity and negatively correlated with the saccade latency. The activity of RDNs was not significantly correlated with the saccade parameters. We further analyzed the CORs for RENs, a major type of CD neurons. First, we examined the time courses of the CORs using a moving time window (duration: 200 ms). The positive correlation with the saccade velocity and the negative correlation with the saccade latency were present not only in the peri-saccadic period but also during the pre- and postcue periods. Second, we asked whether the CORs with the saccade parameters were direction-selective. A majority of RENs were more active before contralateral saccades (contralateral-preferring neurons) and their activity was correlated more strongly with contralateral saccades than with ipsilateral saccades. A minority of RENs, ipsilateral-preferring neurons, showed no such preference. These results are consistent with the hypothesis that CD neuronal activity exerts facilitatory effects on contralateral saccades and that the effects start well before saccade execution. Furthermore, a multiple regression analysis indicated that changes in activity of some, but not all, CD neurons could be explained by changes in saccade parameters; a major determinant was reward context (presence or absence of reward). These results suggest that, while a majority of CD neurons receive reward-related signals, only some of them can make a significant contribution to change saccadic outputs based on expected reward. </jats:p>

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