Neurons in the Primate Orbitofrontal Cortex Respond to Fat Texture Independently of Viscosity
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- Justus V. Verhagen
- University of Oxford, Department of Experimental Psychology, South Parks Road, Oxford OX1 3UD, United Kingdom
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- Edmund T. Rolls
- University of Oxford, Department of Experimental Psychology, South Parks Road, Oxford OX1 3UD, United Kingdom
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- Mikiko Kadohisa
- University of Oxford, Department of Experimental Psychology, South Parks Road, Oxford OX1 3UD, United Kingdom
抄録
<jats:p>The primate orbitofrontal cortex (OFC) is a site of convergence from primary taste, olfactory, and somatosensory cortical areas. We describe the responses of a population of single neurons in the OFC that respond to orally applied fat (e.g., safflower oil) and to substances with a similar texture but different chemical composition, such as mineral oil (hydrocarbon) and silicone oil [(Si(CH<jats:sub>3</jats:sub>)<jats:sub>2</jats:sub>O)<jats:sub>n</jats:sub>]. These findings provide evidence that the neurons respond to the oral texture of fat, sensed by the somatosensory system. Use of an oral viscosity stimulus consisting of carboxymethyl-cellulose in the range 1–10,000 centipoise (cP) showed that the responses of these fat-sensitive neurons are not related to stimulus viscosity. Thus a textural component independent of viscosity and related to the slick or oily property is being used to activate these oral fat-sensitive neurons. Moreover, a separate population of neurons responds to viscosity (produced, e.g., by the carboxymethyl-cellulose series), but not to fat with the same viscosity. Thus there is a dissociation between texture channels used to sense fat viscosity and non–fat-produced viscosity. Further, free fatty acids such as linoleic acid do not activate these neurons, providing further evidence that the oral fat-sensing mechanism through which these OFC neurons are activated is not gustatory but textural. Most of this population of fat-sensitive neurons receive convergent taste inputs. These results provide evidence about how oral fat is sensed and are relevant to understanding the physiological and pathophysiological processes related to fat intake.</jats:p>
収録刊行物
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- Journal of Neurophysiology
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Journal of Neurophysiology 90 (3), 1514-1525, 2003-09
American Physiological Society
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詳細情報 詳細情報について
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- CRID
- 1363670318201214464
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- NII論文ID
- 30010383175
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- ISSN
- 15221598
- 00223077
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