Effect of propentofylline on cerebral metabolism of rats

• V. Stefanovich

抄録

Propentofylline (HWA 285) [3‐methyl‐1‐(5′‐oxohexyl)‐7‐propylxanthine] is in in vitro experiments a good inhibitor of cAMP and cGMP phosphodiesterases in the rat brain and cerebral microvessels. In in vivo experiments it modulates cAMP and cGMP systems and GABA concentration in four examined structures of rats: cortex, hypothalamus, cerebellum, and striatum. Propentofylline (5 mg/kg i.v.) doesn't influence levels of cerebral energy reserves in normal rats but prevents to a significant degree some of the changes in metabolite levels caused by anoxia (30 s of nitrogen breathing). This antianoxic effect occurs at 5 min and disappears 20 min after administaration of the drug. Caffeine (5 mg/kg i.v.) shows a trend toward further aggravation of anoxia. The modulating effect of propentofylline on cAMP and cGMP systems, GABA levels, and especially cererbral enery metabolism in anoxia is possibly related to the potential therapeutic effect of this drug.

収録刊行物

• Drug Development Research

  Drug Development Research 6 (4), 327-338, 1985-01

  Wiley

キーワード

• Drug Discovery

詳細情報

• CRID: 1360855568762997248
• NII論文ID: 30011647588
• DOI: 10.1002/ddr.430060405
• ISSN: 10982299
• ISSN: 02724391
• Web Site: https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fddr.430060405
• Web Site: https://onlinelibrary.wiley.com/doi/pdf/10.1002/ddr.430060405
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