Semiquantitative Morphological Analysis of Stromal Cells the Irradiated and Recovering Rat Thymus.

  • ARUDCHELVAN Yamini
    Department of Oral and Maxillofacial Surgery, Yamaguchi University School of Medicine Department of Anatomy, Yamaguchi University School of Medicine
  • TOKUDA Nobuko
    Department of Anatomy, Yamaguchi University School of Medicine
  • TAMECHIKA Masakatsu
    Department of Anatomy, Yamaguchi University School of Medicine
  • WANG Yu-Hsueh
    Department of Anatomy, Yamaguchi University School of Medicine
  • MIZUTANI Noriko
    Department of Anatomy, Yamaguchi University School of Medicine
  • SAWADA Tomoo
    Department of Anatomy, Yamaguchi University School of Medicine
  • YAMAGUCHI Kazuhito
    Institute of Laboratory Animals, Yamaguchi University School of Medicine
  • FUKUMOTO Tetsuo
    Department of Anatomy, Yamaguchi University School of Medicine
  • SHINOZAKI Fumihiko
    Department of Oral and Maxillofacial Surgery, Yamaguchi University School of Medicine

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To understand the roles of thymic stromal cells in T-lymphocyte development, we semiquantitatively analysed rat thymi recovering from irradiation (6 Gy), using a transmission electron microscope. The most striking findings were that the percentage of subcapsular epithelial cells significantly increased in the cortex on day 3 after irradiation compared with the control; the percentage of intermediate epithelial cells significantly increased in the cortex on days 3 and 5 after irradiation and in the medulla on days 5 and 7 compared with the control; the interdigitating cells disappeared from the medulla by day 7 after irradiation and reappeared on day 9. The present data thus reveal that during recovery after irradiation (6 Gy), marked changes occur in the relative proportions of different epithelial cell subtypes in the cortex and medulla of the rat thymus. In addition, the percentages of macrophages and interdigitating cells also changed during the recovery. These changes, which may be associated with the abrupt proliferation of thymocytes after irradiation, should shed light on the significance of stromal cells in the T cell development.

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