Semiquantitative Morphological Analysis of Stromal Cells the Irradiated and Recovering Rat Thymus.
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- ARUDCHELVAN Yamini
- Department of Oral and Maxillofacial Surgery, Yamaguchi University School of Medicine Department of Anatomy, Yamaguchi University School of Medicine
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- TOKUDA Nobuko
- Department of Anatomy, Yamaguchi University School of Medicine
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- TAMECHIKA Masakatsu
- Department of Anatomy, Yamaguchi University School of Medicine
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- WANG Yu-Hsueh
- Department of Anatomy, Yamaguchi University School of Medicine
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- MIZUTANI Noriko
- Department of Anatomy, Yamaguchi University School of Medicine
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- SAWADA Tomoo
- Department of Anatomy, Yamaguchi University School of Medicine
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- YAMAGUCHI Kazuhito
- Institute of Laboratory Animals, Yamaguchi University School of Medicine
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- FUKUMOTO Tetsuo
- Department of Anatomy, Yamaguchi University School of Medicine
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- SHINOZAKI Fumihiko
- Department of Oral and Maxillofacial Surgery, Yamaguchi University School of Medicine
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抄録
To understand the roles of thymic stromal cells in T-lymphocyte development, we semiquantitatively analysed rat thymi recovering from irradiation (6 Gy), using a transmission electron microscope. The most striking findings were that the percentage of subcapsular epithelial cells significantly increased in the cortex on day 3 after irradiation compared with the control; the percentage of intermediate epithelial cells significantly increased in the cortex on days 3 and 5 after irradiation and in the medulla on days 5 and 7 compared with the control; the interdigitating cells disappeared from the medulla by day 7 after irradiation and reappeared on day 9. The present data thus reveal that during recovery after irradiation (6 Gy), marked changes occur in the relative proportions of different epithelial cell subtypes in the cortex and medulla of the rat thymus. In addition, the percentages of macrophages and interdigitating cells also changed during the recovery. These changes, which may be associated with the abrupt proliferation of thymocytes after irradiation, should shed light on the significance of stromal cells in the T cell development.
収録刊行物
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- Archives of Histology and Cytology
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Archives of Histology and Cytology 63 (2), 147-157, 2000
国際組織細胞学会
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詳細情報
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- CRID
- 1390001206408409984
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- NII論文ID
- 10012977551
- 30012644311
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- NII書誌ID
- AA1068990X
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- COI
- 1:STN:280:DC%2BD3M%2FhvVOhtA%3D%3D
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- ISSN
- 13491717
- 09149465
- http://id.crossref.org/issn/09149465
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- PubMed
- 10885451
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可