The macroscopic, microscopic and spectrometric effects of various chemotherapeutic agents on the plasma‐sprayed hydroxyapatite‐coated implant surface

DOI Web Site Web Site 被引用文献2件

この論文をさがす

抄録

<jats:p>The purpose of this research was to determine the nature of the residual hydroxyapatite (HA)‐coated implant surface after treatment with various chemotherapeutic modalities, including: citric acid, chlorhexidine gluconate, hydrogen peroxide, tetracycline HCl, stannous fluoride, polymyxin B and a prototype plastic Cavitron tip. Implant surfaces were evaluated macroscopically, microscopically (scanning electron microscopy (SEM)) and spectrometrically (energy‐dispersive spectrometry and X‐ray diffraction). HA‐substrate bond strength and dissolution testing was also performed for surfaces treated with a supersaturated citric acid solution. All treatments left either microscopic residues or a loss of surface roughness when viewed on SEM. A 30‐ to 60‐s application of citric acid left a significantly greater coating thickness than all other treatments, whereas a 3‐min application of citric acid removed significantly more HA than untreated controls. Significant changes in CaiP ratios were seen with most treatments. The clinical significance of this phenomenon is not known. No treatments altered the crystallinity of the residual HA coating. A l‐min application of citric acid did not significantly alter the tensile bond strength of the coating to the substrate. The clinical significance of these findings is not known at present. However. when taken with results from previous studies. it appears that in treating the infected HA‐coated implant surface, a 30‐ to 60‐s application of citric acid (pH 1) may be beneficial in detoxifying the HA coating prior to regenerative procedures. Further in vitvo and in viva studies are necessary to evaluate the biological response to citric acid when used to detoxify the infected implant surface.</jats:p>

収録刊行物

被引用文献 (2)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ