IgE‐reactivity to seven <i>Malassezia</i> species

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<jats:title>Abstract</jats:title><jats:p><jats:bold>Background:</jats:bold> <jats:italic>Malassezia</jats:italic> yeasts play a role in the pathogenesis of atopic eczema/dermatitis syndrome (AEDS). The revised genus <jats:italic>Malassezia</jats:italic> includes several species which all are natural habitants of the human skin. In this study, we evaluated the presence of immunoglobulin E (IgE) antibodies to different <jats:italic>Malassezia</jats:italic> spp. in AEDS patients to allow optimization of the characterization of the IgE antibody profile of IgE‐associated AEDS.</jats:p><jats:p><jats:bold>Methods:</jats:bold> Ninety‐six adult patients, with a clinical diagnosis of AEDS, were included in the study. Seventeen of the patients had IgE antibodies to <jats:italic>M. sympodialis</jats:italic>, ATCC 42132 (m70 ImmunoCAP, Pharmacia, Diagnostic AB, Uppsala, Sweden). The IgE antibodies to seven <jats:italic>Malassezia</jats:italic> spp. were measured and inhibition immunoblotting was performed to investigate whether <jats:italic>M. sympodialis</jats:italic> contains all the allergen components present in the other <jats:italic>Malassezia</jats:italic> spp.</jats:p><jats:p><jats:bold>Results:</jats:bold> Twenty per cent of 79 AEDS patients with a negative m70 ImmunoCAP test had IgE antibodies to at least one of the other six <jats:italic>Malassezia</jats:italic> spp. tested. Our inhibition studies indicated that <jats:italic>Malassezia</jats:italic> spp. to a great extent, share allergenic determinants. However, <jats:italic>Malassezia</jats:italic> species also contained species‐specific allergens.</jats:p><jats:p><jats:bold>Conclusion:</jats:bold> The use of only one species of <jats:italic>Malassezia</jats:italic> is not sufficient to detect all patients IgE sensitized to <jats:italic>Malassezia</jats:italic>. To obtain an optimal allergen preparation both common allergenic components as well as species‐specific allergens have to be considered.</jats:p>

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  • Allergy

    Allergy 58 (4), 306-311, 2003-04

    Wiley

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