Molecular analysis of age‐related changes of <i>Streptococcus anginosus</i> group and <i>Streptococcus mitis</i> in saliva

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<jats:p>The purpose of this study was to survey the prevalence of streptococcal species, especially <jats:italic>Streptococcus anginosus</jats:italic> (which has been reported to be associated with cancer in the upper digestive tract), <jats:italic>Streptococcus constellatus</jats:italic>, and <jats:italic>Streptococcus intermedius</jats:italic> in the saliva of different age groups. A sequence analysis of 16S rDNA was performed and DNA quantified using real‐time polymerase chain reaction. The <jats:italic>S. anginosus</jats:italic> level increased with age, whereas the levels of <jats:italic>S. constellatus</jats:italic> and <jats:italic>S. intermedius</jats:italic> did not change. <jats:italic>Streptococcus mitis</jats:italic> was the predominant species in the saliva of all the age groups but, unlike the <jats:italic>S. anginosus</jats:italic>, the proportion of <jats:italic>S. mitis</jats:italic> in the salivary bacteria decreased with age. The increase in <jats:italic>S. anginosus</jats:italic> with age should be carefully monitored because of its association with diseases, including cancer.</jats:p>

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