Biological effects of a purified lipopolysaccharide from Bacteroides gingivalis

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<jats:p>Lipopolysaccharide (LPS) has been purified from <jats:italic>Bacteroides gingivalis</jats:italic>. The purity of this LPS is evidenced on ultracentrifugation, immunoelectrophoresis, and chemical analyses. On comparison with LPS from aerobic enteric organisms, LPS from <jats:italic>Bacteroides gingivalis</jats:italic> exhibits minimal potency when tested for pyrogenicity in rabbits and mitogenicity in mouse spleen cells. On the other hand, purified LPS from <jats:italic>Bacteroides gingivalis</jats:italic> exhibits high potency in its ability to stimulate <jats:sup>45</jats:sup>Ca release from prelabeled fetal rat bones and to inhibit Ca influx into osteoclast‐like cells.</jats:p>

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